103755-46-0Relevant academic research and scientific papers
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-β: Synthesis, biological activity, and cardiovascular safety
Zhang, Han-Cheng,Derian, Claudia K.,McComsey, David F.,White, Kimberly B.,Ye, Hong,Hecker, Leonard R.,Li, Jian,Addo, Michael F.,Croll, Diane,Eckardt, Annette J.,Smith, Charles E.,Li, Quan,Cheung, Wai-Man,Conway, Bruce R.,Emanuel, Stuart,Demarest, Keith T.,Andrade-Gordon, Patricia,Damiano, Bruce P.,Maryanoff, Bruce E.
, p. 1725 - 1728 (2005)
Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. We identified low-nanomolar inhibitors of PKC-β with good to excellent selectivity vs other PKC isozymes and GSK-3β. In a cell-based functional assay, 8f and 8i effectiv
SUBSTITUTED PYRROLINES AS KINASE INHIBITORS
-
Page 70, (2008/06/13)
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
