26663-42-3

Basic information

• Product Name: (1H-INDAZOL-3-YL)-ACETIC ACID
• Synonyms: 2-(1H-INDAZOL-3-YL)ACETIC ACID;(1H-INDAZOL-3-YL)-ACETIC ACID;1H-Indazole-3-acetic acid;(1H-Indazol-3-yl)-acetic acid ,97%;1H-indazol-3-ylacetic acid(SALTDATA: FREE);3-indazoleacetic acid;2-(2H-indazol-3-yl)acetic acid
• CAS NO: 26663-42-3
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 26663-42-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 168 °C (decomp)
• Boiling Point: 434.3 °C at 760 mmHg
• Flash Point: 216.457 °C
• Appearance: /
• Density: 1.438 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: 2-8°C
• PKA: 3.93±0.30(Predicted)
• CAS DataBase Reference: (1H-INDAZOL-3-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-INDAZOL-3-YL)-ACETIC ACID(26663-42-3)
• EPA Substance Registry System: (1H-INDAZOL-3-YL)-ACETIC ACID(26663-42-3)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 26663-42-3(Hazardous Substances Data)

Usage

Chemical Properties

Light red solid

InChI:InChI=1/C9H8N2O2/c12-9(13)5-8-6-3-1-2-4-7(6)10-11-8/h1-4H,5H2,(H,10,11)(H,12,13)

Upstream product

• 271-44-3 benzimidazole 
• 53541-18-7 ethyl 2-(1H-indazol-3-yl)acetate 
• 552-89-6 2-nitro-benzaldehyde 
• 174180-42-8 2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate 
• 101714-15-2 2-(1H-indazol-3-yl)acetonitrile 
• 141-82-2 malonic acid 
• 5678-48-8 3-amino-3-(2-nitrophenyl)propionic acid 
• 102309-00-2 2-hydrazino-cinnamic acid 

Downstream Products

• 131666-74-5 methyl 1H-Indazole-3-ylacetate 
• 1408237-72-8 N-(4-hydroxy-3,5-dimethylphenyl)-2-(1-iso-propyl-1H-indazol-3-yl)-acetamide 
• 1412449-54-7 Methyl 2-(1-(4-chlorobenzoyl)-1H-indazol-3-yl)acetate 
• 1383719-94-5 C₂₇H₃₄N₄O₂ 
• 103755-46-0 2-(1⁽²⁾H-indazol-3-yl)-acetamide 
• 634604-94-7 3-[1-(3-hydroxypropyl)-1H-indazol-3-yl]-4-phenyl-1H-pyrrole-2,5-dione 

Relevant articles and documents

Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our previous lead optimization efforts, we have identified a new ether-based scaffold and paired this with a novel sulfone-based head group to identify a potent and selective GIRK1/2 activator. In addition, we evaluated the compounds in tier 1 DMPK assays and have identified compounds that display nanomolar potency as GIRK1/2 activators with improved metabolic stability over the prototypical urea-based compounds. This journal is

NITROGEN-CONTAINING FUSED RING COMPOUNDS FOR USE AS CRTH2 ANTAGONISTS

The present application relates to nitrogen-containing fused ring compounds shown by general formula (I), a pharmaceutically acceptable salt thereof and a stereoisomer thereof as CRTH2 antagonist, wherein X1, X2, X3, X4, X5, W, X, Y, L1, L2, L3, A, B are as defined in the description; the present application further relates to a method for preparing the compounds, a pharmaceutical formulation and a pharmaceutical composition comprising the compounds, a use of the compounds for the manufacture of a medicament for the treatment and/or prevention of diseases related to activity of CRTH2.

Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase

Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constraint to