2055-52-9

Usage

Methyl ester derivative

1-Phenyl-1H-[1,2,3]triazole-4-carboxylic acid The compound is derived from 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid by attaching a methyl ester group.

Five-membered heterocyclic compound

1,2,3-triazole The core structure of 1-Phenyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester is a five-membered ring containing three nitrogen atoms and two carbon atoms.

Importance in synthesis

Pharmaceuticals, agrochemicals, and materials Triazoles and their derivatives, including 1-Phenyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester, are valuable building blocks in the synthesis of various products.

Potential applications

Synthetic intermediate, pharmaceutical research and development The compound may be used as a synthetic intermediate in organic chemistry or in pharmaceutical research and development.

Specific properties and applications

Dependent on further research and testing The exact properties and potential applications of 1-Phenyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester would need to be determined through additional studies and experiments.

Upstream product

• 68418-90-6 β-nitroacrylate de methyle 
• 622-37-7 Phenyl azide 
• 67-56-1 methanol 
• 34296-51-0 1-phenyl-1,2,3-triazole-4-carbaldehyde 
• 922-67-8 propynoic acid methyl ester 
• 62-53-3 aniline 
• 292638-85-8 acrylic acid methyl ester 
• 107-02-8 acrolein 
• 4967-77-5 methyl 1,2,3-triazole-4-carboxylate 
• 71-43-2 benzene 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 52745-92-3 methyl (E)-3-nitroacrylate 
• 90087-77-7 methyl 3-pyrrolidinoacrylate 
• 110-89-4 piperidine 

Downstream Products

• 942-24-5 3-methoxycarbonylindole 
• 170123-75-8 3-Phenylimino-acrylic acid methyl ester 
• 3198-98-9 dimethyl 1-phenyl-1H-pyrazole-3,4-dicarboxylate 
• 34296-51-0 1-phenyl-1,2,3-triazole-4-carbaldehyde 
• 4600-04-8 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid 
• 103755-58-4 (1-phenyl-1H-1,2,3-triazole-4-yl)methanol 
• 578703-72-7 1-phenyl-1H-1,2,3-triazole-4-carbohydrazide 

Relevant academic research and scientific papers

The azide-alkyne cycloaddition catalysed by transition metal oxide nanoparticles

Colloidal nanoparticles of Earth-abundant, first-row transition metal oxides and sulfide, namely magnetite (Fe3O4), manganese and cobalt ferrite, (MnFe2O4, CoFe2O4), manganese(ii) oxide (Mn

Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants

We describe a photocatalytic system that reveals latent photooxidant behavior from one of the most reducing conventional photoredox catalysts, N-phenylphenothiazine (PTH). This aerobic photochemical reaction engages difficult to oxidize feedstocks, such as benzene, in C(sp2)-N coupling reactions through direct oxidation. Mechanistic studies are consistent with activation of PTH via photooxidation and with Lewis acid cocatalysts scavenging inhibitors inextricably formed in this process.

Design, synthesis and antibacterial evaluation of novel 15-membered 11a-azahomoclarithromycin derivatives with the 1, 2, 3-triazole side chain

Macrolides are widely prescribed in clinic to treat various respiratory tract infections. However, due to their inappropriate use, the prevalence of macrolide-resistant strains among clinical isolates has become a concern for public health. Therefore, nov

Hyperbranched polyethylenimine-supported copper(II) ions as a macroliganted homogenous catalyst for strict click reactions of azides and alkynes in water

Loading hyperbranched polyethylenimine (PEI) with copper(II) ions leads to the formation of a new water-soluble metallodendritic polymer Cu(II)-PEI that has been found to effectively catalyze the clickable azide-alkyne [3 + 2] cycloaddition reactions in w

Catalytic Intermolecular Cross-Couplings of Azides and LUMO-Activated Unsaturated Acyl Azoliums

An example for the catalytic synthesis of densely functionalized 1,2,3-triazoles through a LUMO activation mode has been developed. The protocol is enabled by intermolecular cross-coupling reactions of azides with in situ-generated α,β-unsaturated acyl az

Copper Acetate Catalyzed Regio-selective Synthesis of Substituted 1,2,3-Triazoles: A Versatile Azide–Alk-ene Cycloaddition/Oxidation Approach

A copper acetate catalyzed oxidative cycloaddition reaction of benzyl and aryl azides with terminal and internal olefins that contain electron-withdrawing groups (COOR, CONH2, CN, CHO, COR) has been developed. The reaction employs air as the oxidant and does not require any base or additives to afford 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles in good to excellent yields with high regioselectivity.

Direct access to 1,4-disubstituted 1,2,3-triazoles through organocatalytic 1,3-dipolar cycloaddition reaction of α,β-unsaturated esters with azides

DBU-catalyzed organocatalytic 1,3-dipolar cycloaddition reactions of α,β-unsaturated esters with azides have been developed. This strategy generates 1,4-disubstituted 1,2,3-triazoles in high yields with high regioselectivities. It is demonstrated that some of these products can be transformed into important pharmaceutical agents.

Pressure-accelerated azide-alkyne cycloaddition: Micro capillary versus autoclave reactor performance

Pressure effects on regioselectivity and yield of cycloaddition reactions have been shown to exist. Nevertheless, high pressure synthetic applications with subsequent benefits in the production of natural products are limited by the general availability o

3-nitro- and 3-bromo-3-nitroacrylates in reactions with phenyl azide

1,3-Dipolar cycloaddition of alkyl 3-nitro-and 3-bromo-3-nitroacrylates to phenyl azide gives regioisomeric alkyl 5(4)-nitro-1-phenyl-4,5-dihydro-1H-1,2,3- triazole-4(5)-carboxylates, the corresponding triazoles both with and without nitro group, and alky

Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives

This paper describes the design, synthesis and pharmacological evaluation of new N-acylhydrazone (NAH) compounds, belonging to the N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone class (2a-p). Classical heteroaromatic ring bioisosterism strategies wer