1037586-47-2Relevant academic research and scientific papers
Facile and general synthesis of quaternary 3-aminooxindoles
Marsden, Stephen P.,Watson, Emma L.,Raw, Steven A.
supporting information; experimental part, p. 2905 - 2908 (2009/05/30)
(Chemical Equation Presented) A novel approach to the valuable quaternary 3-aminooxindole skeleton is reported on the basis of intramolecular arylation of enolates of substituted amino acids. The reaction tolerates dialkyl- and arylalkylamines as well as a range of carbon substituents (primary and secondary alkyl, aryl). The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines.
Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis
Jia, Yi-Xia,Hillgren, J. Mikael,Watson, Emma L.,Marsden, Stephen P.,Kuendig, E. Peter
supporting information; experimental part, p. 4040 - 4042 (2009/03/11)
The Pd-catalysed asymmetric intramolecular α-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used. The Royal Society of Chemistry.
