1037586-64-3

Upstream product

• 110-91-8 morpholine 
• 3335-97-5 1-methyl-3-phenylindolin-2-one 
• 100-58-3 phenylmagnesium bromide 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 15757-32-1 3-hydroxy-1-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one 
• 1425058-79-2 1-methyl-2-oxo-3-phenylindolin-3-yl 2,2,2-trichloroacetimidate 
• 103-80-0 phenylacetyl chloride 
• 5215-26-9 N-(2-fluorophenyl)-2-phenylacetamide 
• 348-54-9 2-Fluoroaniline 
• 1386996-00-4 N-(2-fluorophenyl)-N-methyl-2-phenylacetamide 
• 1386996-01-5 N-(2-fluorophenyl)-N-methyl-2-morpholin-2-phenylacetamide 
• 1386996-16-2 2-bromo-N-(2-fluorophenyl)-N-methyl-2-phenylacetamide 
• 66063-37-4 C₁₂H₁₄ClNO₂ 
• 1037586-47-2 N-(2-bromophenyl)-N-methyl-2-morpholin-4-yl-2-phenylacetamide 

Relevant academic research and scientific papers

Synthesis of 3,3-disubstituted oxindoles by one-pot integrated Br?nsted base-catalyzed trichloroacetimidation of 3-hydroxyoxindoles and Br?nsted acid-catalyzed nucleophilic substitution reaction

Treatment of 3-hydroxyoxindoles with trichloroacetonitrile (1.3 equiv.) and a catalytic amount of DBU (0.1 equiv.) followed by addition of nucleophiles (1.5 equiv.) and diphenylphosphoric acid (0.2 equiv.) afforded the 3,3-disubstituted oxindoles in good to excellent yields. DFT computations supported the notion that the reaction went through the 1-alkyl-2-oxo-2H-indol- 1-ium intermediate.

Transition-metal-free synthesis of oxindoles by potassium tert-butoxide-promoted intramolecular α-arylation

Potassium tert-butoxide-mediated intramolecular α-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80 °C. In this manner, diversely substituted products have been obtained in moderate to high yields.

A robust, efficient catalyst system for enolate arylation leading to quaternary 3-aminooxindoles

A catalyst screening programme has revealed that a combination of Pd(0) and the N-heterocyclic carbene ligand SIPr forms a particularly robust and efficient catalyst for the formation of important quaternary 3-aminooxindoles via intramolecular enolate ary

Facile and general synthesis of quaternary 3-aminooxindoles

(Chemical Equation Presented) A novel approach to the valuable quaternary 3-aminooxindole skeleton is reported on the basis of intramolecular arylation of enolates of substituted amino acids. The reaction tolerates dialkyl- and arylalkylamines as well as a range of carbon substituents (primary and secondary alkyl, aryl). The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines.