1037593-39-7Relevant academic research and scientific papers
Microwave-assisted formation of peptide-vitamin conjugates
El-Nachef, Claudia,Bajaj, Kiran,Koblick, Jacqueline,Katritzky, Alan R.
experimental part, p. 4412 - 4419 (2012/09/25)
Amino acid and peptide conjugates with vitamin B3, H, E and D3 were synthesized by using microwave irradiation in good to satisfactory yields. In addition, a novel benzotriazole-activated biotin intermediate has been introduced, whic
Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors
Wang, Qiang,Chen, Maoying,Zhu, Huawei,Zhang, Jie,Fang, Hao,Wang, Binghe,Xu, Wenfang
, p. 5473 - 5481 (2008/12/21)
A series of novel l-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N (APN)/CD13 and matrix metalloproteinase-2 (MMP-2). The preliminary biological test showed that most of the compounds displayed a high inhibitory activity against MMP-2 and a low activity against APN except compound B6 which exhibited good potency (IC50 = 13.2 μM) similar with APN inhibitor Bestatin (IC50=15.5 μM), and could be used as lead compound in the future.
