1037746-99-8

Basic information

• Product Name: tert-butyl 2-(4-nitrophenyl)thiazole-4-carboxylate
• Synonyms: tert-butyl 2-(4-nitrophenyl)thiazole-4-carboxylate
• CAS NO: 1037746-99-8
• Molecular Weight: 306.342
• Mol File: 1037746-99-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-(4-nitrophenyl)thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(4-nitrophenyl)thiazole-4-carboxylate(1037746-99-8)
• EPA Substance Registry System: tert-butyl 2-(4-nitrophenyl)thiazole-4-carboxylate(1037746-99-8)

Safety Data

• Hazardous Substances Data: 1037746-99-8(Hazardous Substances Data)

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 1037746-91-0 tert-butyl 1,3-thiazole-4-carboxylate 

Relevant articles and documents

Direct C-2 arylation of alkyl 4-thiazolecarboxylates: New insights in synthesis of heterocyclic core of thiopeptide antibiotics

(Chemical Equation Presented) The Pd(0)-catalyzed regioselective C-2 (hetero)arylation of tert-butyl 4-thiazolecarboxylate with a broad (hetero)aryl halide is reported, including the direct coupling of pyridinyl halides. The process has allowed the preparation of valuable 2-pyridynyl-4- thiazolecarboxylates which are components of the complex heterocyclic core of thiopeptides antibiotics. As a first application, a synthesis of a tert-butyl sulfomycinamate thio-analogue from tert-butyl 4-thiazolecarboxylate is here described through a three-step direct pyridinylation, halogenation, and Stille cross-coupling sequence.