1037746-91-0

Upstream product

• 3973-08-8 Thiazole-4-carboxylic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1037746-99-8 tert-butyl 2-(4-nitrophenyl)thiazole-4-carboxylate 
• 1037746-97-6 tert-butyl 2-phenylthiazole-4-carboxylate 
• 1037747-05-9 tert-butyl 2-(4-methoxyphenyl)thiazole-4-carboxylate 
• 1037747-01-5 2-(4-cyano-phenyl)-thiazole-4-carboxylic acid tert-butyl ester 
• 1037747-03-7 tert-butyl 2-(4-(methoxycarbonyl)phenyl)thiazole-4-carboxylate 
• 1217902-22-1 tert-butyl 2-(2-phenylpyrimidin-5-yl)thiazole-4-carboxylate 
• 1362690-81-0 C₂₁H₂₁NO₃S 
• 1259374-83-8 tert-butyl 5-(4-methoxyphenyl)-2-phenyl-thiazole-4-carboxylate 
• 1362690-87-6 C₂₂H₁₇N₃O₂S 

Relevant academic research and scientific papers

Palladium-Catalyzed Domino Allenamide Carbopalladation/Direct C-H Allylation of Heteroarenes: Synthesis of Primprinine and Papaverine Analogues

Palladium-catalyzed intramolecular carbopalladation onto allenamides completed by direct C-H allylation of heterocycles is studied. The domino construction/heteroarylation of isoquinolone process is first achieved. A general three-step one-pot strategy, i

Direct C-2 arylation of alkyl 4-thiazolecarboxylates: New insights in synthesis of heterocyclic core of thiopeptide antibiotics

(Chemical Equation Presented) The Pd(0)-catalyzed regioselective C-2 (hetero)arylation of tert-butyl 4-thiazolecarboxylate with a broad (hetero)aryl halide is reported, including the direct coupling of pyridinyl halides. The process has allowed the preparation of valuable 2-pyridynyl-4- thiazolecarboxylates which are components of the complex heterocyclic core of thiopeptides antibiotics. As a first application, a synthesis of a tert-butyl sulfomycinamate thio-analogue from tert-butyl 4-thiazolecarboxylate is here described through a three-step direct pyridinylation, halogenation, and Stille cross-coupling sequence.