103776-64-3Relevant articles and documents
Syntheses of 5,6,7- and 5,7,8-Trioxygenated 3',4'-Dihydroxyflavones Having Alkoxy Groups and Their Inhibitory Activities against Arachidonate 5-Lipoxygenase
Horie, Tokunaru,Tsukayama, Masao,Kourai, Hiroki,Yokoyama, Chieko,Furukawa, Masayuki,et al.
, p. 2256 - 2262 (2007/10/02)
Arachidonate 5-lipoxygenase plays a pivotal role in the biosynthesis of leukotrienes.Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone), a selective inhibitor of the enzyme, was derivatized by introducing alkyl groups of various chain lengths at position