103777-45-3Relevant articles and documents
Method for preparing baicalein
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Paragraph 007; 008; 0021, (2016/10/09)
The invention relates to a method for preparing anti-virus and anti-bacterial inflammatory medicine baicalein. According to the method, phenol serves as a starting material, and a key chalcone intermediate is prepared through bromination, methoxy substitution, Friedel-crafts acylation and aldol condensation; the key intermediate is subjected to oxidative cyclisation and methyl removal reaction, and high-purity baicalein can be prepared. According to the new method, adopted raw reagents are cheap and easy to obtain, the number of synthesis steps is small, reaction operation is easy and convenient, production control is easy, the product yield is high, purity is good, and the method is suitable for production and application of baicalein.