1037827-19-2Relevant academic research and scientific papers
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides
Kling, Andreas,Jantos, Katja,Mack, Helmut,Hornberger, Wilfried,Drescher, Karla,Nimmrich, Volker,Relo, Ana,Wicke, Karsten,Hutchins, Charles W.,Lao, Yanbin,Marsh, Kennan,Moeller, Achim
, p. 7123 - 7138 (2017/09/07)
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to the ide
CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS
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Page/Page column 97, (2008/12/07)
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and 15 the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a' and I-A.a'' in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.
Carboxamide compounds and their use as calpain inhibitors
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Page/Page column 45, (2008/12/08)
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of
