103785-89-3

Basic information

• Product Name: 2-(Diphenyl-phosphinoyl)-1-(4-methoxy-phenyl)-pentan-1-ol
• CAS NO: 103785-89-3
• Molecular Weight: 394.45
• Mol File: 103785-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(Diphenyl-phosphinoyl)-1-(4-methoxy-phenyl)-pentan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Diphenyl-phosphinoyl)-1-(4-methoxy-phenyl)-pentan-1-ol(103785-89-3)
• EPA Substance Registry System: 2-(Diphenyl-phosphinoyl)-1-(4-methoxy-phenyl)-pentan-1-ol(103785-89-3)

Safety Data

• Hazardous Substances Data: 103785-89-3(Hazardous Substances Data)

Upstream product

• 22949-84-4 butyl(triphenyl)phosphonium iodide 
• 123-11-5 4-methoxy-benzaldehyde 
• 4233-13-0 butyldiphenylphosphine oxide 

Relevant articles and documents

The Stereocontrolled Horner-Wittig Reaction: Synthesis of Disubstituted Alkenes

Addition of the lithium derivatives of phosphine oxides Ph2P(O)CH2R1 to aldehydes gives erythro adducts (11) with good stereoselectivity.Reduction of α-diphenylphosphinoyl ketones (12) gives threo adducts (11) with even better stereoselectivity.Purification by flash chromatography and/or crystallisation followed by elimination of Ph2PO2 gives pure Z- or E-alkenes with high material conversion.Explanations are offered for the stereoselectivities, conditions defined for full stereochemical control, and guidelines suggested for approaches to a given alkene.