103789-66-8

Basic information

• Product Name: Benzaldehyde, 4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]-
• CAS NO: 103789-66-8
• Molecular Formula: C18H15NO3
• Molecular Weight: 293.322
• Mol File: 103789-66-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]-(103789-66-8)
• EPA Substance Registry System: Benzaldehyde, 4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]-(103789-66-8)

Safety Data

• Hazardous Substances Data: 103789-66-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 27492-46-2 4,5-dimethyl-2-phenyl-oxazole 3-oxide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 103788-61-0 (5-methyl-2-phenyl-4-oxazolyl)methyl chloride 

Downstream Products

• 159017-59-1 (E)-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylidenepyruvic acid 
• 159017-56-8 ethyl (E)-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)cinnamate 
• 250601-77-5 ethyl (E)-7-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-7-phenylheptanoate 
• 250601-56-0 ethyl (E)-6-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-6-phenylhexanoate 
• 250602-41-6 methyl (E)-2,2-dimethyl-6-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-6-phenylhexanoate 
• 250601-62-8 ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate 
• 250601-50-4 ethyl (E)-3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropionate 
• 250601-83-3 methyl E-4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyrate 
• 250601-04-8 (E)-4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutanoic acid 
• 250601-66-2 ethyl 4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(3-pyridyl)butyrate 
• 250601-51-5 (E)-3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropionic acid 
• 250602-81-4 N-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxy}phtalimide 
• 250602-85-8 4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyamine 
• 250601-34-4 E-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(pyridine-1-oxide-3-yl)acetic acid 

Relevant articles and documents

A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR α/γ dual agonist

The development of a practical and efficient synthesis of a novel PPAR α/γ dual agonist, (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl) amino)acetic acid (1), is described. Development of a stereosele

Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones

A series of 1,2,4-oxadiazolidine-3,5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse - the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy- and ethoxy-linked oxazole 1,2,4-oxadiazolidine-3,5-diones normalized plasma glucose levels at the 100 mg kg-1 oral dose in the db/db diabetic mouse model, and several amongst them reduced the glucose levels at the 20 mg kg-1 oral dose. The most potent compounds in the db/db mouse model were also active in the ob/ob mouse model normalizing the plasma glucose levels at the 20 mg kg-1 oral dose. The trifluoromethoxy analog 32 was the most active compound of the series, reducing significantly the plasma glucose levels at the 5 mg kg-1 oral dose. Oxadiazole-tailed 1,2,4-oxadiazolidine-3,5-diones were also active in both the db/db and ob/ob diabetic mouse models normalizing plasma glucose levels at the 100 mg kg-1 oral dose.

N-HYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS AND INHIBITORS OF OXIDATIVE MODIFICATION OF LOW DENSITY LIPOPROTEIN

This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: wherein: R1 and R3 are independently hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy,