103791-01-1Relevant academic research and scientific papers
Tetrasubstituted pyrrolidines via a tandem aza-Payne/hydroamination reaction
Schomaker, Jennifer M.,Geiser, Andrea R.,Huang, Rui,Borhan, Babak
, p. 3794 - 3795 (2008/02/01)
A facile tandem aza-Payne/hydroamination reaction of aziridinol is reported, which yields highly functionalized pyrrolidines. Addition of alkynyl Grignards to 2,3-aziridinals yields, in most cases, high syn to anti ratios of the aziridinol. Treatment of the syn-aziridinol with base leads initially to an aza-Payne rearrangement, which juxtaposes the amine and the alkyne in favorable orientation to complete the hydroamination. The anti-aziridinol undergoes the aza-Payne rearrangement, but cannot proceed further with the hydroamination. Copyright
Total synthesis of (+)-conagenin
Chakraborty, Tushar Kanti,Sudhakar, Gangarajula
, p. 5847 - 5849 (2007/10/03)
The total synthesis of the immunomodulator, (+)-conagenin was achieved using, as a key step, a method developed by us for the synthesis of 2-methyl-1,3-diols via Ti(III)-mediated diastereo- and regioselective opening of trisubstituted 2,3-epoxy alcohols,
REGIO- AND STEREOSELECTIVE OXIDATION OF ENE-TYPE CHLORINATED OLEFINS.
Suzuki, Shigeaki,Onishi, Takashi,Fujita, Yoshiji,Otera, Junzo
, p. 1123 - 1130 (2007/10/02)
Regio- and stereoselective oxidation of ene-type chlorinated olefins has been achieved by using potassium 2-propanenitronate as an oxidant and tetrakis(triphenylphosphine)palladium as a catalyst.
