103793-23-3Relevant academic research and scientific papers
Oral Hypoglycemic Agents. Discovery and Structure-Activity Relationships of Phenacylimidazolium Halides
Dominianni, Samuel J.,Yen, Terence T.
, p. 2301 - 2306 (2007/10/02)
Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides.Compounds 2 and 3 produced reductions of ca. 40percent 2 h after doses of 100 mg/kg po.Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion.Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.
Imidazolium hypoglycemic agents
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, (2008/06/13)
Imidazolium salts are effective in lowering blood glucose levels in mammals following administration.
