103807-53-0Relevant academic research and scientific papers
Synthesis and enzymatic resolution of Cα-dialkylated α-azido carboxamides: New enantiopure α-azido acids as building blocks in peptide synthesis
Jost, Micha,Sonke, Theo,Kaptein, Bernard,Broxterman, Quirinus B.,Sewald, Norbert
, p. 272 - 278 (2007/10/03)
α-Azido carboxylic acids have recently emerged as versatile N-protected equivalents for α-amino acids, especially valuable when the sterically hindered Cα-dialkylated α-amino acids have to be incorporated. Unsymmetrically substituted Cα/s
A facile synthesis of 2-benzyloxy/2-(4-isopropylbenzyloxy)-2-methyl-3-(4- substituted phenyl)propanoic acid based insulin sensitizing agents: RSR 13-15 and PKR13-15
Verma, Raman K.,Singla, Rubina,Punniyakoti
, p. 660 - 676 (2007/10/03)
The title compounds (RSR13-15) and (PKR13-15) were prepared by the etherification of benzyl alcohol and 4-isopropylbenzyl alcohol respectively with ethyl-2-bromo-2-methyl-3-(4-substituted phenyl)propanoates in the presence of sodium hydride in THF followed by alkaline hydrolysis of the ethyl esters. The substituted propanoic acids used in this synthetic sequence were prepared by magnesium-methanol reduction of correspondingly substituted propenoic acids, which in turn were prepared via 'Perkin Reaction' of 4-substituted benzaldehydes with propanoic anhydride. The details of the synthetic sequence followed for the preparation of all these compounds having almost all the structural features required for a compound to act as a potent insulin sensitizing agent are reported. Birkhaeuser Boston 2004.
SYNTHESES D'ESTERS OU D'ACIDES α-HALOGENES A PARTIR DES GEM DICYANO EPOXIDES.
Robert, A.,Jaguelin, S.,Guinamant, J. L.
, p. 2275 - 2282 (2007/10/02)
α-halogeno esters or α-halogenoacids were easily prepared by selective one pot reaction of gem-dicyano epoxides with halohydric acids in an alcoholic or aqueous media.
