54881-51-5

Upstream product

• 103-79-7 1-phenyl-acetone 
• 109-77-3 malononitrile 

Downstream Products

• 104997-68-4 chloro-(1-chloro-1-methyl-2-phenyl-ethyl)-malononitrile 
• 50870-06-9 1-Amino-3-methyl-2-naphthalenecarbonitrile 
• 42160-26-9 2-amino-4-methyl-5-phenylthiophene-3-carbonitrile 
• 1436461-08-3 tert-butyl 2-amino-3a-benzyl-1-carbamoyl-3-cyano-6-methyl-3a,4-dihydro-1H-pyrrolo[1,2-b]pyrazole-5-carboxylate 
• 1436461-07-2 ethyl 2-amino-3a-benzyl-1-carbamoyl-3-cyano-6-methyl-3a,4-dihydro-1H-pyrrolo[1,2-b]pyrazole-5-carboxylate 
• 84596-15-6 3,3-diethoxy-1-methyl-2-phenylpropylidenepropanedinitrile 
• 103807-53-0 ethyl 2-bromo-2-methyl-3-phenylpropanoate 
• 33441-61-1 3-benzyl-3-methyl-oxirane-2,2-dicarbonitrile 

Relevant academic research and scientific papers

Deconjugative alkylation/Heck reaction as a simple platform for dihydronaphthalene synthesis

A simple platform for carbocycle synthesis by Knoevenagel adduct deconjugative alkylation/Heck reaction is described. Deconjugative alkylation of Knoevenagels adducts is two-fold synthetically enabling because C-C bond formation is (1) operationally simple due to the ease of Knoevenagel adduct carbanion generation and (2) results in alkene migration, which poises the substrate for cyclization. Furthermore, the gem-dinitrile moiety serves as a functional group for synthetic manipulation.

Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized. We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, 5a,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids. All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 μM at the GluR6 receptor.

Solvent-free condensations of ketones with malononitrile catalysed by methanesulfonic acid/morpholine system

The preparation of ylidenemalononitriles via Knoevenagel condensations of ketones with malononitrile under solvent-free conditions is described. Good yields and short reaction time are the features observed with methanesulfonic acid (MSA)/morpholine used as the catalyst. The wide applicability of the protocol is shown by the fact that not only unconjugated, but also aryl-alkyl ketones gave satisfactory yields.

Synthesis and in vitro antifungal activity of 1-amino-3,4-dialkylnaphthalene-2-carbonitriles and their analogues

Twenty-four 3- and/or 4-alkyl-substituted 1-aminonaphthalene-2-carbonitriles and their analogues were prepared and evaluated for growth-inhibiting activity against four phytopathogenic fungi: Fusarium culmorum, Alternaria brassicicola, Botrytis cinerea an

1-Benzoyl-3-(arylphyridyl)urea compounds

The present invention is directed to 1-benzoyl-3-(arylpyridyl)urea compounds useful as insecticides.