1038478-79-3

Upstream product

• 1026017-99-1 2-bromo-4-methyl-7-nitro-2H-1,4-benzoxazin-3(4H)-one 
• 10406-25-4 4-aminobenzyl cyanide 

Downstream Products

• 16292-99-2 2-(methylamino)-5-nitrophenol 
• 105-07-7 4-cyanobenzaldehyde 
• 1038478-95-3 tert-butyl [2-[(2-hydroxy-4-nitrophenyl)(methyl)amino]-2-oxoethyl]carbamate 

Relevant academic research and scientific papers

Ring opening of 2-(benzylamino)-2H-1,4-benzoxazin-3(4H)-ones and 2-bromo-2H-1,4-benzoxazin-3(4H)-ones

Substituted 2-(benzylamino)-2H-1,4-benzoxazin-3(4H)-ones are unstable under alkaline and acidic conditions, undergoing opening of the benzoxazinone ring. 2-Bromo-2H-1,4-benzoxazin-3(4H)-ones show similar degradation under alkaline conditions, while replacement of Br at C(2) to give 2-hydroxy-2H-1,4-benzoxazin- 3(4H)-ones was observed only under mild alkaline conditions. Mechanisms of ring opening and degradation to 2-aminophenol derivatives are proposed.