16292-99-2

Upstream product

• 1038478-79-3 4-{[(3,4-dihydro-4-methyl-7-nitro-3-oxo-2H-1,4-benzoxazin-2-yl)amino]methyl}benzonitrile 
• 1026017-99-1 2-bromo-4-methyl-7-nitro-2H-1,4-benzoxazin-3(4H)-one 
• 4694-91-1 6-nitro-3H-benzooxazol-2-one 
• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 
• 59-49-4 2-Benzoxazolinone 
• 101084-61-1 3-methyl-6-nitrobenzo[d]oxazole-2(3H)-one 

Relevant academic research and scientific papers

Ring opening of 2-(benzylamino)-2H-1,4-benzoxazin-3(4H)-ones and 2-bromo-2H-1,4-benzoxazin-3(4H)-ones

Substituted 2-(benzylamino)-2H-1,4-benzoxazin-3(4H)-ones are unstable under alkaline and acidic conditions, undergoing opening of the benzoxazinone ring. 2-Bromo-2H-1,4-benzoxazin-3(4H)-ones show similar degradation under alkaline conditions, while replacement of Br at C(2) to give 2-hydroxy-2H-1,4-benzoxazin- 3(4H)-ones was observed only under mild alkaline conditions. Mechanisms of ring opening and degradation to 2-aminophenol derivatives are proposed.