1038502-78-1

Basic information

• Product Name: 6-methyl-1-tosyl-4-vinyl-1H-benzo[d][1,3]oxazin-2(4H)-one
• Synonyms: 6-methyl-1-tosyl-4-vinyl-1H-benzo[d][1,3]oxazin-2(4H)-one
• CAS NO: 1038502-78-1
• Molecular Weight: 343.403
• Mol File: 1038502-78-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-methyl-1-tosyl-4-vinyl-1H-benzo[d][1,3]oxazin-2(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-1-tosyl-4-vinyl-1H-benzo[d][1,3]oxazin-2(4H)-one(1038502-78-1)
• EPA Substance Registry System: 6-methyl-1-tosyl-4-vinyl-1H-benzo[d][1,3]oxazin-2(4H)-one(1038502-78-1)

Safety Data

• Hazardous Substances Data: 1038502-78-1(Hazardous Substances Data)

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 34897-84-2 2-amino-5-methylbenzyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes

We present herein a highly diastereo- and enantioselective Pd-catalyzed [4 + 2] cycloaddition of benzofuran-derived azadienes with vinyl benzoxazinanones, which represents a rare highly stereoselective cycloaddition of this class of fused azadienes as a two-atom synthon. The use of a phosphoramidite ligand bearing a chiral secondary amine with a simple biphenyl backbone proved to be the key to construct the novel spirocyclic tetrahydroquinoline scaffold containing three contiguous stereocenters as a single diastereomer in high enantioselectivity.

Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Enantioselective Umpolung Annulations

A combination of NHC organocatalysis and transition-metal catalysis gives rise to fundamentally new cooperative reactivity and enables the regio- and enantioselective annulation reaction between enals and vinyl benzoxazinanones. The cooperative umpolung annulation eliminates mutual deactivation and leads to a diverse set of benzazepine derivatives in good yields with excellent enantioselectivities (up to 99% ee). The development of such a cooperative catalytic system dramatically expands the scope of NHC organocatalysis by opening up new metal-catalyzed reaction pathways for homoenolate intermediates.