34897-84-2

Basic information

• Product Name: 2-AMINO-5-METHYLBENZYL ALCOHOL
• Synonyms: (2-AMINO-5-METHYL-PHENYL)-METHANOL;2-AMINO-5-METHYLBENZYL ALCOHOL
• CAS NO: 34897-84-2
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Product Categories: Amino Alcohols;Organic Building Blocks;Oxygen Compounds
• Mol File: 34897-84-2.mol
• Article Data: 32

Chemical Properties

• Melting Point: 123-126 °C(lit.)
• Boiling Point: 293.2 °C at 760 mmHg
• Flash Point: 131.1 °C
• Appearance: /
• Density: 1.126 g/cm³
• Vapor Pressure: 0.000799mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.48±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-METHYLBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-METHYLBENZYL ALCOHOL(34897-84-2)
• EPA Substance Registry System: 2-AMINO-5-METHYLBENZYL ALCOHOL(34897-84-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 34897-84-2(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-METHYLBENZYL ALCOHOL is a chemical compound with the molecular formula C8H11NO. It is a white solid with the molecular weight of 137.18 g/mol. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 2-AMINO-5-METHYLBENZYL ALCOHOL has the potential to be used as a chiral auxiliary in asymmetric synthesis reactions due to its stereochemistry. It can also be used as a building block for various chemical reactions, making it a versatile and important compound in organic chemistry.

InChI:InChI=1/C8H11NO/c1-6-2-3-8(9)7(4-6)5-10/h2-4,10H,5,9H2,1H3

Upstream product

• 66424-92-8 5-methyl-2-nitrobenzyl alcohol 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 113302-83-3 (2-azido-5-methylphenyl)methanol 
• 183173-40-2 2,2,2-Trifluoro-N-(2-hydroxymethyl-4-methyl-phenyl)-acetamide 
• 1026310-41-7 4-(2-hydroxymethyl-4-methyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 132354-02-0 N-(2-(hydroxymethyl)-4-methylphenyl)-4-methylbenzenesulfonamide 
• 895578-39-9 N-(2-(chloromethyl)-4-methylphenyl)-4-methylbenzenesulfonamide 
• 183173-46-8 N-(2-Bromomethyl-4-methyl-phenyl)-2,2,2-trifluoro-acetamide 
• 113302-66-2 2-azido-5-methylbenzaldehyde 
• 113302-79-7 2-<(2-azido-5-methylbenzylidene)amino>-5-methylindazole 
• 113302-72-0 2-azido-5-methylbenzaldehyde azine 
• 109467-00-7 2-amino-5-methyl-benzaldehyde 
• 932384-66-2 (2-Hydroxymethyl-4-methyl-phenyl)-carbamic acid tert-butyl ester 
• 1004530-80-6 4-((4-methyl-2-(hydroxymethyl)phenylamino)methyl)-3-nitrobenzoic acid 
• 1620102-84-2 tert-butyl (2-(chloromethyl)-4-methylphenyl)carbamate 

Relevant articles and documents

Construction of a benzo[b]azepine skeleton through decarboxylative ylide [6+1] annulations with modified vinyl benzoxazinanones

A Lewis acid-promoted [6+1] annulation between sulfur ylides and modified vinyl benzoxazinanones was described. In this reaction, the newly designed vinyl benzoxazinanones could serve as a novel six-atom synthon, and the key to success is the installation of an electron-withdrawing group on the alkene moiety of the benzoxazinanones. A broad range of substrates are compatible with this mild reaction system, thereby providing a facile and practical approach for constructing a benzo[b]azepine skeleton.

Metal-Free C-C/C-N/C-C Bond Formation Cascade for the Synthesis of (Trifluoromethyl)sulfonylated Cyclopenta[ b]indolines

A bis(triflyl)ethylation [triflyl = (trifluoromethyl)sulfonyl] inserted into a sequential cyclization cascade resulted in the direct formation of gem-bis(triflyl)ated cyclopenta[b]indolines from anilide-derived allenols and alkenols. This catalyst- and irradiation-free sequence facilitated the efficient preparation of functionalized tricyclic indoline cores bearing two contiguous stereocenters. The formed cyclopenta[b]indolines can be easily transformed into a wide variety of triflylated indolines, including the tetracycle ring system found in polyveoline.

Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement

α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.