10386-81-9

Usage

Uses

Used in Organic Synthesis:
2-Benzyl-2-carbomethoxycyclopentanone is used as a building block in organic synthesis for its ability to undergo various chemical reactions such as oxidation, reduction, and addition reactions. This allows for the creation of a wide range of different compounds, making it a versatile component in the development of new chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-benzyl-2-carbomethoxycyclopentanone is utilized as a key intermediate in the preparation of various pharmaceuticals. Its unique structure and reactivity contribute to the synthesis of new drug candidates, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2-benzyl-2-carbomethoxycyclopentanone serves as a crucial intermediate for the synthesis of agrochemicals. Its involvement in the production of these chemicals can lead to the development of new pesticides, herbicides, or other agricultural products that improve crop yields and protect against pests.

Upstream product

• 33228-99-8 Dimethyl 2-methylidenehexane-1,6-dioate 
• 98-80-6 phenylboronic acid 
• 28557-00-8 phenylzinc chloride 
• 1002353-03-8 6-ethyl 1-methyl 2-methylenehexanedioate 
• 1002353-06-1 6-benzyl 1-methyl 2-methylenehexanedioate 
• 100-44-7 benzyl chloride 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 627-93-0 hexanedioic acid dimethyl ester 
• 4897-84-1 Methyl 4-bromobutyrate 
• 100-39-0 benzyl bromide 

Downstream Products

• 249537-14-2 methyl rac-1-benzyl-2-oxocyclopent-3-enecarboxylate 
• 2867-63-2 2-benzylcyclopentanone 
• 1262726-19-1 methyl 1-benzyl-2-(trimethylsilyloxy)cyclopent-2-enecarboxylate 
• 1262726-29-3 methyl (1R,4S,7s)-7-benzyl-2,3-diiodobicyclo[2.2.1]hepta-2,5-diene-7-carboxylate 
• 68767-14-6 loxoprofen 

Relevant academic research and scientific papers

Reduction of 2-alkyl-2-carbomethoxy-cyclopentanone derivatives with sodium borohydride. Part 2. The elucidation of the diastereoselective control

The synthesis and reduction of four new 2-substituted β-keto-ester derivatives (6-9) employing inexpensive sodium borohydride, were achieved to evaluate the diastereoselectivity of the reduction process of 2-allyl-2- carbomethoxy cyclopentanone derivative

A substituted phenylacetic acid derivatives (by machine translation)

The invention belongs to the field of drug synthesis, relates to a substituted phenylacetic acid derivatives, in particular to the preparation of 2 - [4 - (2 - methyl oxygen fifth heavenly stem) hydrocinnamic acid] preparation method. If nitrile alkylation reaction include alkylation reaction, reaction or ester alkyl [...] reaction to prepare the intermediate type II - 2 or type II - 2' compound, After the hydrolytic reaction or oxidation reaction preparation to obtain the product. The invention relates to the alkylation reaction without additional solvent, is a more industrialization of the advantages of the line. (by machine translation)

γ-Lactone Synthesis via Palladium(II)-Catalyzed Lactonization of Unactivated Methylene C(sp3)-H Bonds

A palladium(II)-catalyzed intramolecular lactonization of unactivated methylene C(sp3)-H bonds using PIP bidentate auxiliary is described. This method provides an efficient and concise pathway to synthesize functionalized γ-lactones.

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

Systematic SAR optimization of the GPR119 agonist lead 1, derived from an internal HTS campaign, led to compound 29. Compound 29 displays significantly improved in vitro activity and oral exposure, leading to GLP1 elevation in acutely dosed mice and reduc

Synthesis of enantiopure 1-r-alkyl-2-c,5-t-diphenylphospholanes and phospholanium salts through direct alkylation of phospholane

Chiral enantiopure 1-alkyl-2,5-diphenylphospholanium salts were obtained in one step through alkylation of phospholane with alkyl triflates. The resulting air-stable phosphonium salts are electron-rich trialkylphosphane precursor ligands for transition metals, and they offer a convenient route toward chiral quaternary phosphonium salts as phase-transfer agents. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

A new method for constructing quaternary carbon centres: Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation

The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.

Cyclopentane carboxylate compounds, process and intermediates for preparing the same and use thereof

The present invention discloses cyclopentane carboxylate compounds. The 1-hydrocarbyl-2-acyloxy-cyclopentane carboxylates according to the invention have a general formula (I): wherein groups R1, R2 and R3, which are ident

CYCLOPENTANE CARBOXYLATE COMPOUNDS, PROCESS AND INTERMEDIATES FOR PREPARING THE SAME AND USE THEREOF

The present invention discloses cyclopentane carboxylate compounds. The I-hydrocarbyl-2-acyloxy-cyclopentane carboxylates according to the invention have a general formula (I): wherein groups R1, R2 and R3, which are ident

Pd(OAc)2-catalyzed carbonylation of amines

A phosphine-free catalytic system [Pd(OAc)2-Cu(OAc) 2-air] induced a substrate-specific carbonylation of amines in boiling toluene under CO gas (1 atm). Symmetrical N,N′-dialkylureas were obtained by the carbonylation of primary amines. N,N,N′-Trialkylureas were selectively formed by addition of a secondary amine to the above reaction vessel. Secondary amines did not give tetraalkylureas. However, dialkylamines with a phenyl group on their alkyl chains, such as N-monoalkylated benzylic amine or phenethylamine derivatives, underwent a direct aromatic carbonylation to afford five- or six-membered benzolactams. In the carbonylation, the chelation effect or steric repulsion between Pd(II) and the meta-substituent in the ortho-palladation and the ring sizes of cyclopalladation products that were formed prior to carbonylation were found to generate good site selectivity and increase the reaction rate. In contrast, carbonylation of ω- arylalkylamines with a hydroxyl group gave neither ureas nor benzolactams but instead produced 1,3-oxazolidinones smoothly. Hydrochlorides of amines also underwent carbonylation to afford the corresponding amides under the conditions used. This procedure made it possible to prepare ureas of amino acid esters and N-alkylcarbamates in practical yields.

Baeyer-Villiger oxidations catalyzed by engineered microorganisms: Enantioselective synthesis of δ-valerolactones with functionalized chains

Cyclohexanone monooxygenase (CHMO) from Acinetobacter sp NCIMB 9871 expressed in baker's yeast and in E. coli and cyclopentanone monooxygenase (CPMO) from Comamonas (previously Pseudomonas) sp. NCIMB 9872 expressed in E. coli are new bioreagents for Baeye