1038778-75-4Relevant academic research and scientific papers
Gold(i) catalyzed tandem cyclization of propargylic esters to 4-acyloxy-1,2-dihydroquinolines
Sun, Yuan-Ming,Gu, Peng,Gao, Yu-Ning,Xu, Qin,Shi, Min
supporting information, p. 6942 - 6945 (2016/06/06)
An effective synthetic protocol for structurally diverse 4-acyloxy-1,2-dihydroquinoline compounds has been accomplished by a gold(i)-catalyzed tandem [3,3]-rearrangement and intramolecular hydroamination of propargylic esters, affording the desired products in good yields. Moreover, the asymmetric variant of this cyclization has also been achieved using a chiral nitrogen acyclic carbene (NAC) gold(i) complex. These products have application in the enantioselective synthesis of an aromatase inhibitor within three simple steps.
A novel entry to cyclopenta[b]quinolines via thermal ring-expansion of (2-aminophenyl)-ethynyl-substituted squaric acid derivatives
Zehr, Peter S.,Kayali, Reem,Pe?a-Cabrera, Eduardo,Robles-Resendiz, Omar,Villanueva-Rendon, Alma D.,S?derberg, Bj?rn C.G.
, p. 5336 - 5344 (2008/09/21)
Substituted cyclopenta[b]quinolin-1-ones were prepared by thermal ring-expansion of substituted N-Boc protected 4-(2-aminophenylethynyl)-4-hydroxy-2-cyclobuten-1-ones forming the corresponding 2-aminophenylmethylidene substituted 4-cyclopentene-1,3-diones. Deprotection of the amine resulted in spontaneous condensation giving cyclopenta[b]quinolin-1-ones. Sodium borohydride reduction of these products produced cyclopenta[b]quinolin-1-ols.
