1038783-21-9

Basic information

• Product Name: (R)-4-hydroxy-N,N-dimethyl-2-methylidene-4-phenylbutanamide
• CAS NO: 1038783-21-9
• Molecular Weight: 219.283
• Mol File: 1038783-21-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-hydroxy-N,N-dimethyl-2-methylidene-4-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-hydroxy-N,N-dimethyl-2-methylidene-4-phenylbutanamide(1038783-21-9)
• EPA Substance Registry System: (R)-4-hydroxy-N,N-dimethyl-2-methylidene-4-phenylbutanamide(1038783-21-9)

Safety Data

• Hazardous Substances Data: 1038783-21-9(Hazardous Substances Data)

Upstream product

• 26613-71-8 4-phenyl-2-methylenebutyrolactone 
• 124-40-3 dimethyl amine 

Relevant articles and documents

A stereodivergent synthesis of β-hydroxy-α-methylene lactones via vinyl epoxides

A catalytic diastereoselective sulfonium ylide epoxidation of aldehydes furnished original vinyl epoxides, having an MBH backbone. These highly functionalised building blocks were used for a formal synthesis of the antibiotic conocandin, and opened up a stereodivergent route towards β-hydroxy-α-methylene lactones, core units of naturally occurring compounds. Under acidic conditions, the oxiranes were mainly transformed, with moderate to good yields, into trans β-hydroxy-α-methylene lactones. On the other hand, a user-friendly palladium-catalysed CO2 insertion and cyclisation sequence gave the cis β-hydroxy-α-methylene lactone counterparts along with an interesting cis-trans equilibration of the π-allyl intermediates. The Royal Society of Chemistry.