1038997-69-1

Basic information

• Product Name: C₂₂H₃₀NO₃P
• Synonyms: C₂₂H₃₀NO₃P
• CAS NO: 1038997-69-1
• Molecular Weight: 387.459
• Mol File: 1038997-69-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₀NO₃P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₀NO₃P(1038997-69-1)
• EPA Substance Registry System: C₂₂H₃₀NO₃P(1038997-69-1)

Safety Data

• Hazardous Substances Data: 1038997-69-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1809-19-4 dibutyl hydrogen phosphite 
• 92-29-5 hydrobenzamide 

Downstream Products

• 1300734-70-6 dibutyl((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate 
• 1300734-60-4 dibutyl ((5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamido)-(phenyl)methyl)phosphonate 
• 1300734-65-9 dibutyl((5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-arboxamido)(phenyl)methyl)phosphonate 
• 1038997-74-8 C₇H₈O₃S*C₁₅H₂₆NO₃P 
• 1347739-97-2 O,O-di-n-butyl [2-(4,6-dimethoxypyrimidin-2-yloxy)phenoxyamino](phenyl)methylphosphonate 
• 1357284-98-0 O,O'-dibutyl {[2-(2-chloro-4-fluorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1357284-97-9 O,O'-dibutyl {[2-(4-methoxyphenoxy)acetamido](phenyl)methyl}phosphonate 
• 1357284-95-7 O,O'-dibutyl {[2-(2,4,5-trichlorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1357284-94-6 O,O'-dibutyl {[2-(3-methyl-4-chlorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1357284-93-5 O,O'-dibutyl {[2-(2-methyl-4-chlorophenoxy)acetamido](phenyl)methyl}phosphonate 
• 1192761-57-1 C₃₁H₄₇N₄O₃PS₂ 
• 1192761-56-0 C₃₁H₄₇N₄O₃PS₂ 
• 1192761-49-1 C₂₉H₄₃N₄O₃PS₂ 
• 1192761-60-6 O,O'-di-n-butyl isothiocyanato(phenyl)methylphosphonate 

Relevant articles and documents

Synthesis and cytotoxicity of O,O′-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates

A series of O,O′-dialkyl {[2-(substituted phenoxy)acetamido] (substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC50 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.

Synthesis and biological evaluation of novel phosphonates derivatives of as potential antitumor agents

A series of dialkyl [2-(4,6-dimethoxypyrimidin-2-yloxy)benzamido](aryl) methylphosphonates derivatives were designed and synthesized. All the new compounds were identified by elemental analysis, IR, 1H NMR, 31P NMR, and MS. Their antitumor activity against KB and CNE1 cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further study of structure modification. In particular, the compounds 6i and 6j displayed more potent cytotoxic activities against KB in comparison with 5-FU. Copyright Taylor & Francis Group, LLC.