1038997-71-5

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 92-29-5 (E,E)-1,3,5-triphenyl-2,4-diazapenta-1,4-diene 
• 92-29-5 hydrobenzamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 1300734-64-8 diisopropyl ((5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate 
• 1300734-69-3 diisopropyl((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate 
• 1300734-59-1 diisopropyl ((5-chloro-1,3-dimethyl-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate 
• 1192761-59-3 O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate 
• 1352612-48-6 diisopropyl (3-(6-fluorobenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate 
• 1352612-52-2 diisopropyl (3-(4-methylbenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate 
• 1352612-56-6 diisopropyl (3-(6-methoxybenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate 
• 1352612-60-2 diisopropyl (3-(6-ethoxybenzo[d]thiazol-2-yl)thioureido)(phenyl)methylphosphonate 
• 112564-57-5 diisopropyl [amino(phenyl)methyl]phosphonate 

Relevant academic research and scientific papers

Synthesis and antiviral activity of novel pyrazole amides containing α-aminophosphonate moiety

A series of novel pyrazole amides J1-J15 containing an α-aminophosphonate moiety were synthesized and subsequently characterized by spectral (IR, 1H-, 13C-, 31P-, and 19F-NMR) data and elemental analysis. The racemic sample of J1 was further separated into its enantiomers under normal-phase condition on two immobilized polysaccharide-based chiral stationary phases (Chiralpak IA and Chiralpak IC). The synthesized compounds revealed certain degree of antiviral activity in the bioassay. The title compounds (J 3, J10, and J12) showed some curative activities (39.9%, 41.8%, 50.1%, respectively) against tobacco mosaic virus at 0.5 mg/mL.

Synthesis and bioactivities of α-aminophosphonate derivatives containing benzothiazole and thiourea moieties

The synthesis of a series of novel α-aminophosphonate derivatives containing benzothiazole and thiourea moieties from substituted 2-aminobenzothiazoles and synthetic intermediates O,O'-dialkylisothiocyanat- (phenyl)methylphosphonates under microwave irradiation has been demonstrated. Several salient features, such as good to excellent yields, shorter reaction times, milder reaction conditions, and simple purification procedures, make the present synthetic protocol highly attractive to access the title compounds. Bioassays indicated that most of the compounds possessed broad-spectrum insecticidal and antiviral activities against Tobacco Mosaic Virus (TMV) in vivo. Interestingly, in comparison with control insecticide Avermectin, two compounds displayed remarkably high in vitro insecticidal activities against Plutella xylostella. Furthermore, according to the results from preliminary bioassay, all were associated with moderate to good anti-TMV activities. [Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: Tables S1-S4. Figures S1-S52.] Copyright Taylor and Francis Group, LLC.