1038997-75-9Relevant academic research and scientific papers
Design and Synthesis of 2,2′-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Livendahl, Madeleine,Jamroskovic, Jan,Ivanova, Svetlana,Demirel, Peter,Sabouri, Nasim,Chorell, Erik
supporting information, p. 13004 - 13009 (2016/09/09)
G-quadruplex (G4) structures carry vital biological functions, and compounds that selectively target certain G4 structures have both therapeutic potential and value as research tools. Along this line, 2,2′-diindolylmethanes have been designed and synthesi
Palladium-catalyzed direct arylation of indoles with cyclohexanones
Chen, Shanping,Liao, Yunfeng,Zhao, Feng,Qi, Hongrui,Liu, Saiwen,Deng, Guo-Jun
supporting information, p. 1618 - 1621 (2014/04/17)
A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-arylindoles as the sole products.
DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS
-
, (2012/03/26)
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.
"on water" direct and site-selective Pd-catalysed C-H arylation of (NH)-indoles
Joucla, Lionel,Batail, Nelly,Djakovitch, Laurent
supporting information; experimental part, p. 2929 - 2936 (2011/02/22)
This communication describes the development of a versatile catalytic system based on palladium(II) acetate/bis(diphenylphosphino)methane [Pd(OAc)2/dppm] that works "on water" giving site-selective C-H arylation of (NH)-indoles without protecting or directing groups. Remarkably, the control of regioselectivity was achieved by small changes in the "extra-catalytic" base/halide partners. These innovative methodologies allow a high-yielding access to both C2 and C3-arylindoles, as well as 2,3-diarylindoles, and display high chemo/regioselectivities and structural versatility with regard to either indole or aryl moieties. Copyright
CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS
-
Page/Page column 36-37, (2009/12/28)
There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof wherein one of R1 and R2 is H and the other is COOH. The compounds are useful as PPAR modulators.
Cu(II)-catalyzed direct and site-selective arylation of indoles under mild conditions
Phipps, Robert J.,Grimster, Neil P.,Gaunt, Matthew J.
supporting information; experimental part, p. 8172 - 8174 (2009/02/02)
We have developed a new site-selective Cu(II)-catalyzed C-H bond functionalization process that can selectively arylate indoles at either the C3 or C2 position under mild conditions. The scope of the arylation process is broad and tolerates broad functionality on both the indole and aryl unit, which makes it amenable to further elaboration. The mechanism of the arylation reaction is proposed to proceed via a Cu(III)-aryl species that undergoes initial electrophilic addition at the C3 position of the indole motif. We speculate that site of indole arylation arises through a migration of the Cu(III)-aryl group from C3 to C2, and this can be controlled by the nature of the group on the nitrogen atom; free (NH)- and N-alkylindoles deliver the C3-arylated product, whereas N-acetylindoles afford the C2 isomer, both with excellent yield and selectivity. Copyright
