10390-06-4Relevant articles and documents
Synthesis, Physicochemical and Pharmacological Properties of N,N′,N″, N?-Substituted Amides of 1,1,3,3- Propanetetracarboxylic Acid
Bezuglyi,Georgiyants,Perekhoda,Garnaya,Sych
, p. 475 - 477 (2007/10/03)
By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N′,N″,N?- substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.