1039171-10-2Relevant articles and documents
MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE
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, (2009/10/09)
The invention provides compounds inhibitory to the Hepatitis C viral protease, compositions and combinations including the compounds, methods of treatment of conditions wherein inhibition of the Hepatitis C viral protease is medically indicated, and metho
MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS
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Page/Page column 48, (2008/12/07)
The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.