10394-96-4Relevant articles and documents
Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III)
Rupanawar, Bapurao D.,Veetil, Sruthi M.,Suryavanshi, Gurunath
, p. 6232 - 6239 (2019)
Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.
Zirconium-mediated multicomponent reactions of 1,3-butadiynes with ylidenemalononitriles to form functionalized 1,8-naphthyridine and cyclopenta[b]pyridine derivatives
Yu, Shasha,Sun, Renhong,Chen, Haoyi,Xie, Xin,Liu, Yuanhong
, p. 1420 - 1424 (2015)
Zirconocene-mediated multicomponent reactions of 1,3-butadiynes with ylidenemalononitriles in the absence or presence of CuCl have been developed. In the absence of CuCl, 1,3-butadiyne couples with three molecules of ylidenemalononitriles to yield azazirconacycles bearing a hexahydro-1,8-naphthyridine skeleton with high stereoselectivity. In the presence of CuCl, cyclopenta[b]-pyridine or cyclopenta[ b ]quinolin-1-one derivatives are obtained via transmetalation of Zr-C bond to Cu-C bond as the key reaction step. These domino-type reactions proceed with high chemo-, regio- and/or stereoselectivities, and allowing the formation of multiple C-N and C-C bonds in a single operation.
-
Charles
, p. 2468 (1956)
-
The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions
Jain, Kavita,Chaudhuri, Saikat,Pal, Kuntal,Das, Kalpataru
supporting information, p. 1299 - 1304 (2019/01/21)
The Knoevenagel condensation between active methylene compounds and aromatic carobonyl compounds has been developed using quinine as an organocatalyst to afford various electrophilic alkenes in excellent yields (up to 90%). In the presence of a catalytic amount of quinine (15 mol%), the reaction proceeded at room temperature (RT) under solvent-free conditions. In this green approach, the organocatalyst was recovered and recycled for up to four cycles without appreciable loss of activity.
Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles
Liu, Yingtian,Dang, Xinxin,He, Yu,Bai, Hudong,Chen, Xuehong,Li, Jun-Long,Fan, Junting,Jiang, Hezhong,Li, Jiahong
, p. 662 - 671 (2019/02/20)
A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit
