103963-35-5

Basic information

• Product Name: 4-[(R)-5-Hydroxyheptyl]-3-methyl-2(5H)-furanone
• Synonyms: 4-[(R)-5-Hydroxyheptyl]-3-methyl-2(5H)-furanone;Isoseiridin
• CAS NO: 103963-35-5
• Molecular Formula: C12H20 O3
• Molecular Weight: 212.2854
• Mol File: 103963-35-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 371.2°Cat760mmHg
• Flash Point: 157.2°C
• Appearance: /
• Density: 1.043g/cm³
• Vapor Pressure: 5.04E-07mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: 4-[(R)-5-Hydroxyheptyl]-3-methyl-2(5H)-furanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(R)-5-Hydroxyheptyl]-3-methyl-2(5H)-furanone(103963-35-5)
• EPA Substance Registry System: 4-[(R)-5-Hydroxyheptyl]-3-methyl-2(5H)-furanone(103963-35-5)

Safety Data

• Hazardous Substances Data: 103963-35-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H20O3/c1-3-11(13)7-5-4-6-10-8-15-12(14)9(10)2/h11,13H,3-8H2,1-2H3/t11-/m1/s1

Upstream product

• 157123-02-9 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate 
• 516-09-6 4-hydroxy-3-methyl-5H-furan-2-one 
• 557-20-0 diethylzinc 
• 1026715-60-5 5-(4-Methyl-5-oxo-2,5-dihydro-furan-3-yl)-pentanal 

Relevant articles and documents

Palladium Catalysed Cross-Coupling of Vinyl Triflates with 9-Alkyl-9-borobicyclononanes. Total Synthesis of (-)-Isoseiridine.

Pd(O) Catalysed cross-coupling of butenolide-3-triflates to 9-alkyl-9-borobicyclononanes occurs in moderate to good yield and tolerates a range of functionality.Application of this methodology combined with addition of diethylzinc to a butenolide aldehyde in the presence of an ephedrine derivative leads to a 3-step synthesis of (-)-isoseiridine with 88percent e.e. in good yield.