157123-02-9

Basic information

• Product Name: 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate
• Synonyms: 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate
• CAS NO: 157123-02-9
• Molecular Formula: C₆H₅F₃O₅S
• Molecular Weight: 246.1611096
• Mol File: 157123-02-9.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate(157123-02-9)
• EPA Substance Registry System: 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate(157123-02-9)

Safety Data

• Hazardous Substances Data: 157123-02-9(Hazardous Substances Data)

Upstream product

• 516-09-6 4-hydroxy-3-methyl-5H-furan-2-one 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 51461-34-8 ethyl 4-bromo-2-methyl-3-oxobutanoate 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 

Downstream Products

• 1278561-38-8 C₂₆H₄₄O₃Si₂ 
• 1279719-15-1 5-hydroxy-4-(4-hydroxyphenyl)-3-methylfuran-2(5H)-one 
• 1278561-35-5 C₁₇H₂₄O₃Si 
• 1548292-84-7 8-benzyl-6-hydroxy-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one 
• 857054-02-5 3-methyl-2H-furo[2,3-c]pyran-2-one 
• 103963-35-5 (+)-isoseiridine 
• 103963-35-5 (-)-isoseiridine 

Relevant articles and documents

New and scalable access to karrikin (KAR1) and evaluation of its potential application on corn germination

Karrikin (KAR1), also named ‘karrikinolide’, was isolated in 2004 from smoke water and identified as a very potent germination stimulant as well as controlling early seedling development for a large variety of plant species. We reported herein an unprecedented and scalable synthesis of Karrikin (KAR1) based on an elegant and efficient 6-endo-dig cyclization. Moreover, we evaluated the effect of KAR1 on corn seeds germination, we carried out additional studies on the uptake of this butenolide into corn seeds, and the main soil chemiodynamic properties (i.e., persistence and mobility) were calculated or estimated. Finally, we provided a rationalization of the experimental results by building a homology model of corn KAI2, using as template the X-ray of the KAI2 protein from Arabidopsis thaliana.

A synthetic approach to enfumafungin

The stereospecific synthesis of the dienophile subunits 5 was achieved from the butenolide 6. Ester 19 was obtained in 67% overall yield (2 steps), with no intermediate purification, by a sodium chlorite oxidation of the corresponding aldehyde in buffered

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I : (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and proph