103977-78-2Relevant articles and documents
Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors
Chang, Yu,Lu, Xiaoyun,Shibu, Marthandam Asokan,Dai, Yi-Bo,Luo, Jinfeng,Zhang, Yan,Li, Yingjun,Zhao, Peng,Zhang, Zhang,Xu, Yong,Tu, Zheng-Chao,Zhang, Qing-Wen,Yun, Cai-Hong,Huang, Chih-Yang,Ding, Ke
, p. 5927 - 5932 (2017)
A series of N-(3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides were designed as the first class of highly selective ZAK inhibitors. The representative compound 3h strongly inhibits the kinase activity of ZAK with an IC50 of 3.3 n
GCN2 MODULATOR COMPOUNDS
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Paragraph 187, (2021/08/27)
The disclosures herein relate to novel compounds of Formula (1): or a salt thereof, wherein X, Y, R1, R2, R3, R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with General Control Nondepressible 2 (GCN2).
Alkylene phenylsulfonamide type selective ZAK inhibitor and application thereof
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Paragraph 0105; 0106; 0119-0121, (2018/06/16)
The invention relates to application of an alkylene phenylsulfonamide compound with a structure of formula (I) (shown in the description) or pharmaceutically acceptable salt thereof or stereisomer thereof or a prodrug molecule thereof in preparation of a