103977-79-3

Basic information

• Product Name: 3-Bromo-2,4-difluoroaniline
• Synonyms: 3-Bromo-2,4-difluoroaniline;3-Bromo-2,4-difluorophenylamine;BenzenaMine, 3-broMo-2,4-difluoro-;2-bromo-1,3-difluoro-4-aminobenzene;3-Amino-2,6-difluorobromobenzene
• CAS NO: 103977-79-3
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.0034664
• Mol File: 103977-79-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 224.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.788±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.19±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2,4-difluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2,4-difluoroaniline(103977-79-3)
• EPA Substance Registry System: 3-Bromo-2,4-difluoroaniline(103977-79-3)

Safety Data

• Hazardous Substances Data: 103977-79-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-2,4-difluoroaniline is a chemical compound with the molecular formula C6H4BrF2N. It is an aromatic amine that contains a bromine atom and two fluorine atoms attached to the benzene ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It can also be used as a building block for the production of dyes, pigments, and other specialty chemicals. 3-Bromo-2,4-difluoroaniline is a reactive compound and should be handled with care due to its potential hazards, including skin and eye irritation.

Upstream product

• 64248-56-2 1-bromo-2,6-difluorobenzene 
• 103977-78-2 2-bromo-1,3-difluoro-4-nitrobenzene 

Relevant articles and documents

GCN2 MODULATOR COMPOUNDS

The disclosures herein relate to novel compounds of Formula (1): or a salt thereof, wherein X, Y, R1, R2, R3, R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with General Control Nondepressible 2 (GCN2).

Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

A series of N-(3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides were designed as the first class of highly selective ZAK inhibitors. The representative compound 3h strongly inhibits the kinase activity of ZAK with an IC50 of 3.3 n

N-(3-ethynyl-2,4-difluorophenyl)sulfonamide derivatives as selective Raf inhibitors

A series of N-(3-ethynyl-2,4-difluorophenyl)sulfonamides were identified as new selective Raf inhibitors. The compounds potently inhibit B-RafV600E with low nanomolar IC50 values and exhibit excellent target specificity in a selectivity profiling investigation against 468 kinases. They strongly suppress proliferation of a panel of human cancer cell lines and patient-derived melanoma cells with B-RafV600E mutation while being significantly less potent to the cells with B-RafWT. The compounds also display favorable pharmacokinetic properties with a preferred example (3s) demonstrating significant in vivo antitumor efficacy in a xenograft mouse model of B-RafV600E mutated Colo205 human colorectal cancer cells, supporting it as a promising lead compound for further anticancer drug discovery.