103985-13-3Relevant academic research and scientific papers
A facile synthetic route for antineoplastic drug GDC-0449
Cao, Meng,Hu, Hua-You,Zhao, Hu-Cheng,Zhang, Xi-Quan,Gu, Hong-Mei,Yang, Ling,Cai, Jin,Wang, Peng,Hu, Bing,Ji, Min
, p. 1408 - 1414 (2014)
In the current study a facile synthetic route for preparing antineoplastic drug GDC-0449 is investigated. Starting with pyridine-1-oxide and 1-iodo-3-nitrobenzene, the intermediate product 2-(2-chloro-5-nitrophenyl) pyridine was prepared by cross-coupling
Method for preparing Vismodegib
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Paragraph 0142-0144, (2017/04/28)
The invention provides a preparation method for vismodegib, and in other words, a preparation method for 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)benzamide. The method comprises: firstly preparing an intermediate 2-(3-nitrophenyl)py
Palladium-catalyzed direct C-H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates
Li, Mengli,Li, Xing,Chang, Honghong,Gao, Wenchao,Wei, Wenlong
supporting information, p. 2421 - 2426 (2016/03/01)
An efficient ligand-free Pd(OAc)2-catalyzed selective arylation of pyridine N-oxides using potassium (hetero)aryltrifluoroborates as coupling partners via C-H bond activation was achieved in the presence of TBAI. This approach has a broad subst
Antiallergic agents. 2. N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides
Honma,Oda,Hashiyama,Hanamoto,Nakai,Inoue,Ishida,Takeda,Ono,Tsuzurahara
, p. 1499 - 1504 (2007/10/02)
A new series of N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides was prepared to determine the effects of substituents on the benzene and pyridine rings on antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay after oral administr
