103985-13-3Relevant articles and documents
A facile synthetic route for antineoplastic drug GDC-0449
Cao, Meng,Hu, Hua-You,Zhao, Hu-Cheng,Zhang, Xi-Quan,Gu, Hong-Mei,Yang, Ling,Cai, Jin,Wang, Peng,Hu, Bing,Ji, Min
, p. 1408 - 1414 (2014)
In the current study a facile synthetic route for preparing antineoplastic drug GDC-0449 is investigated. Starting with pyridine-1-oxide and 1-iodo-3-nitrobenzene, the intermediate product 2-(2-chloro-5-nitrophenyl) pyridine was prepared by cross-coupling
Palladium-catalyzed direct C-H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates
Li, Mengli,Li, Xing,Chang, Honghong,Gao, Wenchao,Wei, Wenlong
supporting information, p. 2421 - 2426 (2016/03/01)
An efficient ligand-free Pd(OAc)2-catalyzed selective arylation of pyridine N-oxides using potassium (hetero)aryltrifluoroborates as coupling partners via C-H bond activation was achieved in the presence of TBAI. This approach has a broad subst