104-28-9 Usage
Uses
Different sources of media describe the Uses of 104-28-9 differently. You can refer to the following data:
1. Cinoxate is an organic compound used as an ingredient in some types of sunscreens. Cinoxate is an ester formed from methoxycinnamic acid and 2-ethoxyethanol. Cinoxate is a slightly yellow viscous liqu
id that is insoluble in water, but miscible with alcohols, esters, and vegetable oils.
Cinoxate protects skin against the sun by absorbing UV-A and UV-B rays.
2. cinoxate (2-hydroxy-p-methoxycinnamate) is an FDA-approved sunscreen chemical with an approved usage level of 1 to 3 percent. Studies indicate it causes photosensitivity.
3. Cinoxate is an organic compound used as an ingredient in some types of sunscreens. Cinoxate is an ester formed from methoxycinnamic acid and 2-ethoxyethanol. Cinoxate is a slightly yellow viscous liquid that is insoluble in water, but miscible with alcohols, esters, and vegetable oils.Cinoxate protects skin against the sun by absorbing UV-A and UV-B rays.
General Description
Viscous clear to pale yellow liquid. Insoluble in water.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
cinoxate may hydrolyze under acidic or alkaline conditions.
Fire Hazard
cinoxate is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 104-28-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104-28:
(5*1)+(4*0)+(3*4)+(2*2)+(1*8)=29
29 % 10 = 9
So 104-28-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O4/c1-3-17-10-11-18-14(15)9-6-12-4-7-13(16-2)8-5-12/h4-9H,3,10-11H2,1-2H3
104-28-9Relevant articles and documents
Carboxylic Acid Reductase Can Catalyze Ester Synthesis in Aqueous Environments
Pongpamorn, Pornkanok,Kiattisewee, Cholpisit,Kittipanukul, Narongyot,Jaroensuk, Juthamas,Trisrivirat, Duangthip,Maenpuen, Somchart,Chaiyen, Pimchai
supporting information, p. 5749 - 5753 (2021/02/01)
Most of the well-known enzymes catalyzing esterification require the minimization of water or activated substrates for activity. This work reports a new reaction catalyzed by carboxylic acid reductase (CAR), an enzyme known to transform a broad spectrum of carboxylic acids into aldehydes, with the use of ATP, Mg2+, and NADPH as co-substrates. When NADPH was replaced by a nucleophilic alcohol, CAR from Mycobacterium marinum can catalyze esterification under aqueous conditions at room temperature. Addition of imidazole, especially at pH 10.0, significantly enhanced ester production. In comparison to other esterification enzymes such as acyltransferase and lipase, CAR gave higher esterification yields in direct esterification under aqueous conditions. The scalability of CAR catalyzed esterification was demonstrated for the synthesis of cinoxate, an active ingredient in sunscreen. The CAR esterification offers a new method for green esterification under high water content conditions.