10401-59-9

Usage

Uses

Different sources of media describe the Uses of 10401-59-9 differently. You can refer to the following data:
1. Fluorescent probe for direct carboxylic acid modification.
2. 9-Anthryldiazomethane (ADAM) is a fluorescent diazomethane analog used to identify bile acids, amino acids, fatty acids, steroid acids, and prostaglandins. In addition, derivatives of 9-Anthryldiazomethane can be detected using liquid chromatography-mass spectrometry. Furthermore, the fluorescence of these analogs can be detected at 254nm and 412 nm. Alternate studies indicate that 9-Anthryldiazomethane can be used to identify prostaglandins in plasma assays using HPLC.

InChI:InChI=1/C15H10N2/c16-17-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-10H

Upstream product

• 7512-18-7 anthracen-9-ylmethylene-hydrazone 

Downstream Products

• 16430-34-5 9-(phenoxymethyl)anthracene 
• 38418-19-8 Benzoesaeure(anthr-9-ylmethylester) 
• 157606-35-4 okadaic acid 9-anthrylmethylester 

Related news

Phorbol myristate acetate-stimulated release of cyclooxygenase products in rat pleural cells: Derivatization of prostaglandins with 9-ANTHRYLDIAZOMETHANE (cas 10401-59-9) for fluorometric determination by high performance liquid chromatography08/05/2019

White cells were collected from the wash of rat pleural cavity after exsanguination. The incubation mixture of the pleural cells with 1 μM phorbol myristate acetate (PMA) was extracted with acidified ethanol and purified with a Sep-pak C18. The resultant fraction containing prostaglandins (PG) ...detailed

Assessment of fatty acids in cardiac tissue as 9-ANTHRYLDIAZOMETHANE (cas 10401-59-9) esters by high-performance liquid chromatography08/02/2019

A high-performance liquid chromatographic technique for the rapid assessment of fatty acids in cardiac tissue is described. A level of 50.4 ± 14.9 nmol fatty acids per g wet weight of rat myocardial tissue could be monitored. The content of the individual fatty acids C14:0, C16:0, C16:1, C18:0,...detailed

Improved method for preparation and use of 9-ANTHRYLDIAZOMETHANE (cas 10401-59-9) for derivatization of hydroxycarboxylic acids08/01/2019

Application of a method for the “in situ” generation of 9-anthryldiazomethane (ADAM) to the derivatization of the carboxyl function in diarrhetic shellfish poisoning (DSP) toxins revealed the formation of artifact products. Using liquid chromatography–mass spectrometry, it was determined that...detailed

New preparation method for 9-ANTHRYLDIAZOMETHANE (cas 10401-59-9) (ADAM) as a fluorescent labeling reagent for fatty acids and derivatives07/30/2019

A preparation method for 9-anthryldiazomethane (ADAM) as a fluorescent labeling reagent for carboxylic acids is described. 9-Anthraldehyde hydrazone is oxidized with an organic oxidant, N-chlorosuccinimide, in an organic solvent such as ethyl acetate to give ADAM, and then the reaction mixture i...detailed

Relevant academic research and scientific papers

Absolute Configurational Assignment of Acyclic Hydroxy Carboxylic Acids: A New Strategy in Exciton-Coupled Circular Dichroism

A new strategy in exciton-coupled circular dichroism (ECCD) is described for the configurational assignment of α-hydroxy carboxylic acids.Using 9-anthryldiazomethane (4), carboxyl groups can be selectively derivatized with a chromophore suitable for exciton coupling.In combination with the 2-naphthoate chromophore linked to the α-hydroxy group, the absolute stereochemistry of α-hydroxy carboxylic acids can be easily deduced from a single CD measurement.The usefulness of the new method is demonstrated with a series of α-hydroxy acids with different side chains.The developed microscale method is also useful for chiral amino acids and natural products containing carboxylic groups or similar strucutral units.

Diazo preparation via dehydrogenation of hydrazones with "activated" DMSO

We report that "activated" dimethyl sulfoxide efficiently dehydrogenates hydrazones to the respective diazo species at -78°C. Under optimized conditions, triethylamine hydrochloride is removed quantitatively by vacuum filtration to provide solutions of diazo compounds. Stable diazo species can be isolated in high yield, or alternatively, the direct treatment of these solutions with carboxylic acids provides esters.