1040101-01-6

Usage

Uses

Used in Pharmaceutical Industry:
1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMOis used as a pharmaceutical intermediate for the synthesis of various organic compounds and pharmaceuticals. Its bromine substituent makes it a valuable building block in the development of biologically active molecules.
Used in Drug Discovery and Development:
1H-INDAZOLE-7-CARBOXYLIC ACID, 3-BROMOis used as a compound with potential anti-inflammatory and anti-cancer properties. It is being studied for its potential applications in the development of new drugs for the treatment of various diseases, particularly those related to inflammation and cancer.

Upstream product

• 945762-00-5 3-bromo-7-cyano-1H-indazole 

Relevant academic research and scientific papers

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preference for constitutive NOS over inducible NOS. By contrast, 1H-indazole-7-carboxamide (8) was slightly less potent but demonstrated a surprising selectivity for the neuronal NOS. Further substitution of 6 by a Br-atom at carbon-3 of the heterocycle enhanced 10-fold the inhibitory effects. Inhibition of NO formation by 6 appeared to be competitive versus both substrate and the cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H4B). In close analogies with 1, compound 6 strongly inhibited the NADPH oxidase activity of nNOS and induced a spin state transition of the heme-FeIII. Our results are explained with the help of the X-ray structures that identified key-features for binding of 1 at the active site of NOS.