104017-61-0Relevant articles and documents
Anticonvulsant 4-Aryl Semicarbazides and Thioureas
Nagarajan, K.,David, J.,Rajappa, S.,Talwalker, S.
, p. 934 - 939 (2007/10/02)
Among a series of anticonvulsant 1-aryl semicarbazides, 1-(3,5-bistrifluoromethyl)phenylsemicarbazide, C 3884-Go (11) and its 4-methyl derivative, C 3165-Go (12) showed good activity of long duration in the electroshock test in mice and rats.Quantitative structure activity analysis indicates that ? and ? values are respectively important for the aromatic and side chain substituents respectively.N-Acetyl-N'-(3,5-bistrifluoromethyl)phenyl hydrazine (20) is highly anticonvulsant but causes ataxia. 4-Aryl thiosemicarbazides show weak to moderate activity.Among N-(3,5-bistrifluoromethyl)phenyl thiocarbamoyl derivatives, the product 33 from N-benzyl piperazine is potent in the electroshock test.Compounds 11 and 12 have been compared with standards such as phenytoin, phenurone and carbamazepine.