1040264-69-4Relevant articles and documents
Potent triazolyl-proline-based inhibitors of HCV NS3 protease
Naud, Julie,Lemke, Christopher,Goudreau, Nathalie,Beaulieu, Eric,White, Peter D.,Llinas-Brunet, Montse,Forgione, Pat
body text, p. 3400 - 3404 (2009/04/06)
The design and synthesis of tripeptide-based inhibitors of the HCV NS3 protease containing a novel P2-triazole is described. Replacement of the P2 quinoline with a triazole moiety provided a versatile handle which could be expediently modified to generate a diverse series of inhibitors. Further refinement by the incorporation of an aryl-substituted triazole and replacement of the P1 acid with an acyl sulfonamide ultimately provided inhibitors with interesting cellular activity.
