340771-31-5

Usage

Uses

Used in Organic Chemistry Research:
1-Ethynyl-4-(methylsulphonyl)-benzene is used as a research compound for studying its properties and reactivity in organic chemistry. It contributes to the development of new compounds and reactions, advancing the field of organic chemistry.
Used in Pharmaceutical Industry:
1-Ethynyl-4-(methylsulphonyl)-benzene is used as a building block or intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the creation of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
1-Ethynyl-4-(methylsulphonyl)-benzene is used as a reactant in various chemical synthesis processes. Its ethynyl and methylsulfonyl functional groups enable it to participate in a range of chemical reactions, leading to the formation of diverse products.
Used in Material Science:
1-Ethynyl-4-(methylsulphonyl)-benzene can be used in the development of new materials with specific properties. Its incorporation into polymers or other materials can result in materials with unique characteristics, such as improved stability or enhanced reactivity.
Used in Environmental Applications:
1-Ethynyl-4-(methylsulphonyl)-benzene may be employed in environmental applications, such as the development of new methods for pollutant detection or remediation. Its chemical properties could be harnessed to create innovative solutions for environmental challenges.

InChI:InChI=1/C9H8O2S/c1-3-8-4-6-9(7-5-8)12(2,10)11/h1,4-7H,2H3

Upstream product

• 113854-19-6 trimethyl((4-(methylsulfonyl)phenyl)ethynyl)silane 
• 56041-85-1 4-ethynylthioanisole 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 3466-32-8 4-bromoohenyl methyl sulfone 

Downstream Products

• 923026-49-7 4-[4-(methylsulfonyl)phenyl]-1-[(3-phenylprop-2-yn-1-yl)oxy]but-3-yn-2-one 
• 1040264-69-4 C₃₅H₄₇N₇O₉S₂ 
• 1414890-78-0 C₁₉H₂₀BrClO₃SZn 
• 1414890-76-8 6-o-tolyl-hex-5-ynenitrile 
• 1414890-72-4 (E)-1-[5-chloro-2-(4-methylsulfanyl-phenyl)-pent-1-enyl]-4-methanesulfonyl-benzene 
• 1414890-79-1 1-(5-chloro-pent-1-ynyl)-4-methanesulfonyl-benzene 
• 1400887-99-1 C₂₉H₂₈F₃NO₅S₂ 
• 1400887-98-0 C₂₈H₂₆F₃NO₅S₂ 
• 1400887-97-9 Amgen₅₄ 
• 1400887-96-8 C₂₈H₂₈F₃NO₅S₂ 
• 1400887-95-7 C₂₆H₂₁F₆NO₅S₂ 
• 1400887-94-6 C₂₅H₁₉F₆NO₅S₂ 

Relevant academic research and scientific papers

Pyridylidene Amide Ru Complex for Selective Oxidation in Organic Synthesis

The ruthenium(II) bis(PYA) complex 1 (PYA = p-pyridylidene amide) is a powerful catalyst for the oxidation of sulfides to sulfones, of alkenes to carbonyl compounds, and of terminal alkynes to carboxylic acids by using NaIO4 as the terminal oxidant. The catalytic system shows a broad functional group tolerance and rate differences between alkyne and sulfide oxidation that are sufficiently large to effectively achieve selective sulfide oxidation with exquisite selectivity.

Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex molecules with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O=U=O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation. This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogues by late-stage oxygenation in an atom- and step-efficient manner.

Novel valdecoxib derivatives by ruthenium?II)-promoted 1, 3-dipolar cycloaddition of nitrile oxides with alkynes - Synthesis and COX-2 inhibition activity

Novel valdecoxib-based cyclooxygenase-2 inhibitors were synthesized in one step via 1, 3-dipolar cycloaddition of nitrile oxides with a series of eleven aryl alkynes, six of them described for the first time. Application of Ru?II)-catalysis leads preferab

One-pot synthesis of 1, 2-disubstituted 4-, 5-, 6-, and 7-azaindoles from amino-o-halopyridines via n-arylation/sonogashira/cyclization reaction

A direct synthesis of several 1, 2-disubstituted 4-, 5-, 6-, and 7-azaindoles from available amino-o-halopyridines is described. This procedure involves a palladium-catalyzed N-arylation followed by a Sonogashira reaction and subsequent cyclization in a one-pot manner, exhibiting a wide scope and compatibility with electron-withdrawing and electron-donating groups. The strategy represents an advancement in azaindole chemistry with a straightforward approach toward 1, 2-disubstituted azaindoles, while avoiding complex N-arylations of hindered 2-substituted azaindoles and difficult purification steps of intermediates.

Transition-metal-free regioselective synthesis of alkylboronates from arylacetylenes and vinyl arenes

A transition-metal-free synthesis of alkylboronates, utilizing arylacetylenes or vinyl arenes and bis(pinacolato)diboron through tandem borylation and protodeboronation, has been developed. This reaction is efficient, practical and environmentally benign, leading to anti-Markovnikov products with excellent regioselectivity, broad functional group tolerance and excellent yields in both small and gram scales.

NOVEL CONDENSED PYRAZOLE DERIVATIVE AND MEDICAL USES THEREOF

PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent for mood disorder, anxiety disorder, schizophrenia, dementia, drug dependence or the like related to subtypes of metabolism type glutamate receptor (mGlu) 2 and 3. SOLUTION: There are prov

MediaChrom: Discovering a Class of Pyrimidoindolone-Based Polarity-Sensitive Dyes

A small library of six polarity-sensitive fluorescent dyes, nicknamed MediaChrom, was prepared. This class of dyes is characterized by a pyrimidoindolone core fitted out with a conjugated push-pull system and a carboxy linker for a conceivable coupling wi

Click reaction as a tool to combine pharmacophores: The case of Vismodegib

Abstract The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors

A group of regioisomeric 3,4,6-triphenylpyran-2-ones with a MeSO 2 pharmacophore at the paraposition of either a C-3 phenyl or a C-4 phenyl substituent on the central six-membered pyran-2-one ring were prepared and evaluated in vitro for their