1040281-86-4

Usage

Uses

Used in Organic Synthesis:
Methyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate is used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and materials, due to its versatile reactivity and compatibility with a wide range of chemical reactions.
Used in the Suzuki-Miyaura Cross-Coupling Reaction:
In the field of organic chemistry, Methyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate is used as a reagent in the Suzuki-Miyaura cross-coupling reaction. This reaction is crucial for connecting aromatic or heteroaromatic compounds, facilitating the formation of carbon-carbon bonds and contributing to the creation of complex molecular structures.
Used in Drug Discovery and Development:
Methyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate is utilized in the construction of small molecule libraries, which are essential for drug discovery and development. Its presence in these libraries allows for the exploration of new chemical entities with potential therapeutic applications.
Used in Pharmaceutical Industry:
Methyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate is used as a key intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate is employed in the synthesis of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Materials Science:
Methyl 4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate is also used in the development of new materials with specific properties, such as conductivity, stability, or biocompatibility, for applications in various industries, including electronics, energy, and medicine.

Upstream product

• 22913-26-4 methyl thiophene-3-carboxylate 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 
• 25240-59-9 pinacolboronic acid 
• 88770-19-8 5-bromothiophene-3-carboxylic acid methyl ester 

Downstream Products

• 130655-92-4 5-p-tolyl-thiophene-3-carboxylic acid methyl ester 
• 1392440-56-0 C₁₃H₁₀O₃S 

Relevant academic research and scientific papers

PKB inhibitor

The invention provides a PKB inhibitor, particularly relates to a compound shown as a formula I or a pharmaceutically acceptable salt thereof. The invention further provides a preparation method of the compound.

NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

A C-H borylation approach to suzuki-miyaura coupling of typically unstable 2-heteroaryl and polyfluorophenyl boronates

A method for the synthesis of biaryls and heterobiaryls from arenes and haloarenes without the intermediacy of unstable boronic acids is described. Pinacol boronate esters that are analogous to unstable boronic acids are formed in high yield by iridium-catalyzed C-H borylation of heteroarenes and fluoroarenes. These boronates are stable in the solid state or in solution and can be generated and used in situ. They couple with aryl halides in the presence of simple palladium catalysts, providing a convenient route to biaryl and heteroaryl products that have been challenging to prepare via boronic acids.

Iridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C-H functionalization

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, additional functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed. High regioselectivities were observed in borylation of 3- and 2,5-di-substituted thiophenes. Electrophilic aromatic C-H/C-Si bromination on thiophene boronate esters is shown to take place without breaking the C-B bond, and one-pot C-H borylation/Suzuki-Miyaura cross-coupling has been accomplished on 2- and 3-borylated thiophenes.