1040310-41-5Relevant academic research and scientific papers
Enantioselective reduction of benzofuranyl aryl ketones
Carpenter, Ian,Clarke, Matthew L.
supporting information; experimental part, p. 65 - 68 (2011/02/25)
Enantioselective transfer hydrogenation of benzofuranyl aryl ketones proceeds with moderate to good enantioselectivity even when the aryl group is not sterically differentiated by ortho-substituents. The best results are obtained with substrates that are functionalised by electron-withdrawing aryl groups that contrast with the electron-rich benzofuran, which is consistent with [Ru-ArC-H]·Ar π interactions acting as a control element. Enantioselective pressure hydrogenation gives lower enantioselectivity irrespective of electronic effects, unless the aryl group is ortho-substituted, in which case up to 86% ee can be realised. Georg Thieme Verlag Stuttgart - New York.
