42926-52-3

Basic information

• Product Name: 2-Ethoxybenzoyl chloride
• Synonyms: 2-ETHOXYBENZOYL CHLORIDE;O-ETHOXYBENZOYL CHLORIDE;2-Ethoxybenzoyl Chloride o-Ethoxybenzoyl Chloride;Benzoyl chloride, 2-ethoxy- (9CI);2-Ethoxybenzoyl chloride 98%;2-Ethoxybenzoyl chlo;Sildenafil Chloro IMpurity;Ethoxybenzoyl chlorid
• CAS NO: 42926-52-3
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• EINECS: 256-003-4
• Product Categories: ACIDHALIDE;Aromatic Halides (substituted);Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 42926-52-3.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 114-118°C 5mm
• Flash Point: >110
• Appearance: /
• Density: 1.19
• Vapor Pressure: 0.00677mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Benzene
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-Ethoxybenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxybenzoyl chloride(42926-52-3)
• EPA Substance Registry System: 2-Ethoxybenzoyl chloride(42926-52-3)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 42926-52-3(Hazardous Substances Data)

Usage

General Description

2-Ethoxybenzoyl chloride is a chemical compound with the molecular formula C10H11ClO2. It is a colorless to pale yellow liquid that is used as a reagent in organic synthesis for the preparation of esters, amides, and carboxylic acids. It is a versatile and reactive compound that is commonly used in the pharmaceutical and agrochemical industries. 2-Ethoxybenzoyl chloride is a key intermediate in the synthesis of various pharmaceutical compounds and is also used as a coupling agent in the production of dyes and pigments. It is important to handle this compound with caution, as it is corrosive and can cause severe skin and eye irritation upon contact.

InChI:InChI=1/C9H9ClO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3

Upstream product

• 119-36-8 methyl salicylate 
• 134-11-2 2-ethoxybenzoic acid 

Downstream Products

• 16386-47-3 2-ethoxy-benzoic acid benzo[1,3]dioxol-5-yl ester 
• 112819-13-3 2-ethoxy-benzoic acid-(1-phenyl-2-pyrrolidino-ethyl ester); hydrochloride 
• 102476-73-3 2-ethoxy-benzoic acid-(1-phenyl-2-piperidino-ethyl ester); hydrochloride 
• 69079-96-5 2-ethoxy-benzoic acid-(N-hydroxy-anilide) 
• 109105-27-3 2-ethoxy-benzoic acid-(2-dimethylamino-ethylamide); hydrochloride 
• 10263-57-7 N-(2-ethoxy-benzoyl)-glycine 
• 140836-59-5 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-2-ethoxy-benzamide 
• 123825-39-8 2-ethoxybenzoylcyanomethylenetriphenylphosphorane 
• 94686-72-3 2-Aethoxy-benzoat des 4-tert.-Butyl-guajacols 
• 16447-83-9 2-diazo-1-(2-ethoxyphenyl)propan-1-one 
• 177903-42-3 (2-Ethoxy-benzoyl)-phosphonic acid dimethyl ester 
• 287378-77-2 2-ethoxy-N-(9-deoxyepicinchonine-9-yl)benzamide 
• 168626-58-2 2-ethoxy-N-[4-(5-oxo-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-benzamide 
• 859788-45-7 6-bromo-3-(2-ethoxy-benzoylamino)-imidazo[1,2-a]pyridine-2-carboxylic acid amide 

Relevant articles and documents

Process for preparing O-ethoxybenzoic acid chloride (by machine translation)

The method comprises the following steps of (1) ethylation reaction, (2) alkali hydrolysis reaction and (3) acyl chlorination reaction, and is simple in reaction step, strong in operability, mild in reaction conditions, simple in process, easy to control, convenient to use and capable of easily controlling the byproduct HCl and CO. 2 The method is simple in process, convenient to operate, low in raw material cost, high in yield, good in quality and convenient for industrial production. (by machine translation)

Sedinafine derivatives of the microwave-assisted method for preparing

The invention discloses a microwave-assisted synthesis method of sildenafil derivatives, which mainly comprises the following steps: by using 2-alkoxybenzoic acid and 4-amino-1-methyl-3-n-propyl-1H-pyrazolyl-5-formamide as initial raw materials, carrying out amidation, cyclization, mononitration, nitro reduction, guanidylation and the like to obtain the sildenafil derivatives. The method greatly shortens the reaction time, enhances the reaction efficiency, has the advantages of high yield and high purity, is simple to operate and easy to control, and is beneficial to industrial production of sildenafil analogs.

Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics

Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.