10404-90-7

Basic information

• Product Name: 3-(2-chloro-5,10-dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• CAS NO: 10404-90-7
• Molecular Formula: C₁₇H₁₉ClN₂O₂S
• Molecular Weight: 350.863
• Mol File: 10404-90-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2-chloro-5,10-dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chloro-5,10-dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine(10404-90-7)
• EPA Substance Registry System: 3-(2-chloro-5,10-dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine(10404-90-7)

Safety Data

• Hazardous Substances Data: 10404-90-7(Hazardous Substances Data)

Upstream product

• 50-53-3 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 92-39-7 2-chlorophenothiazine 
• 69-09-0 chlorpromazine hydrochloride 
• 969-99-3 chlorpromazine sulfoxide 
• 1672-76-0 Chlorpromazine oxide 

Relevant articles and documents

Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites

The antimycobacterial activities of chlorpromazine and its metabolites were evaluated alone and in combination with antitubercular drugs. Although associated with limited antimycobacterial activity when tested individually, chlorpromazine and its metabolites exhibited clear synergy when tested in combination with a number of aminoglycosides as well as the active metabolite of rifampicin, 25-desaceteylrifampicin. The combination of chlorpromazine and spectinomycin was associated with the greatest synergy, yielding a fractional inhibitory concentration index (FICI) of 0.31. Synergistic interactions were also observed for combinations of 7-hydroxychlorpromazine or nor-chlorpromazine with kanamycin, streptomycin, spectinomycin and 25-desacetylrifampicin (FICI 0.19-0.5).

Synthesis of the N-oxides of phenothiazine antipsychotic agents

Chlorpromazine N-oxide, fluphenazine N(4')-oxide, prochlorperazine N(4')- oxide, sulforidazine N-oxide, and trifluoperazine N(4')-oxide were synthesized by oxidation of the designated nitrogen atom in the N-10 side chain of the respective parent drug with 3-chloroperoxybenzoic acid. In the case of trifluoperazine, a stepwise increase in the amount of oxidant yielded the N(1'),N(4')-dioxide and N(1'),N(4'),S-trioxide. The N',S-dioxides of chlorpromazine and sulforidazine were obtained by hydrogen peroxide oxidation of the appropriate parent drug.