Metabolism of phenothiazines: identification of N oxygenated products by gas chromatography and mass spectrometry

Article abstract of DOI:10.1111/j.2042-7158.1975.tb09451.x

The solid inlet mass spectra of N oxide and N oxide sulfoxide metabolites of promazine, chlorpromazine and levomepromazine (methotrimeprazine) have been determined at different temperatures and compared with the mass spectra of the main thermolytic product of the N oxides and N oxide sulfoxides obtained during combined gas chromatography mass spectrometry. Diagnostic ions were produced by direct insertion of the compounds at ambient temperature into the mass spectrometer. These ions distinguish the N oxides of arylalkyl tertiary amines from the N oxygenated derivatives of primary and secondary arylalkylamines.