1040461-79-7Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of some 3-(2-methylphenyl)-2- substituted amino-quinazolin-4(3H)-ones as analgesic and anti-inflammatory agents
Alagarsamy, Veerachamy,Solomon, Viswas Raja,Murugesan, Sankaranarayanan
, p. 174 - 181 (2008/09/19)
A variety of novel 3-(2-methylphenyl)-2-substituted amino-quinazolin-4(3H)- ones were synthesized by reacting the amino group of 2-hydrazino-3-(2- methylphenyl)-quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(2-methylphenyl)-quinazolin-4(3H)-one was synthesized from 2-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. Among these, the compound 2-(1-ethylpropylidene)-hydrazino-3-(2-methylphenyl)-quinazolin-4(3H)- one emerged as the most active compound for analgesic activity, while the compound 2-(1-methylbutylidene)-hydrazino-3-(2-methylphenyl)-quinazolin-4(3H)- one showed most potent anti-inflammatory activity of the series and was moderately more potent in its anti-inflammatory activity when compared to the reference standard diclofenac sodium (CAS 15307-86-5). Interestingly, the test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid (CAS No: 50-78-2). ECV - Editio Cantor Verlag.
