66679-64-9

Basic information

• Product Name: 2,4(1H,3H)-Quinazolinedione, 3-(2-methylphenyl)-, 2-hydrazone
• CAS NO: 66679-64-9
• Molecular Formula: C15H14N4O
• Molecular Weight: 266.302
• Mol File: 66679-64-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Quinazolinedione, 3-(2-methylphenyl)-, 2-hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Quinazolinedione, 3-(2-methylphenyl)-, 2-hydrazone(66679-64-9)
• EPA Substance Registry System: 2,4(1H,3H)-Quinazolinedione, 3-(2-methylphenyl)-, 2-hydrazone(66679-64-9)

Safety Data

• Hazardous Substances Data: 66679-64-9(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 37641-48-8 3-(2-methylphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline 
• 97945-03-4 2-(3-o-Tolyl-thioureido)-benzoic acid methyl ester 
• 17425-17-1 N-(2-methylphenyl)-methyl dithiocarbamic acid 
• 53278-67-4 o-tolyl-dithiocarbamic acid; sodium salt 
• 37641-48-8 3-(o-methylphenyl)-2-thioquinazolin-4(3H)-one 
• 332159-52-1 3-(2-methylphenyl)-2-methylsulfanyl-3H-quinazolin-4-one 
• 1040461-53-7 3-(2-methylphenyl)-2-methylsulfanyl-3H-quinazolin-4-one 

Downstream Products

• 1040461-95-7 2-(N'-(4-methyl-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 66679-86-5 2-(N'-(4-chloro-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 1040461-79-7 2-(N'-(2-chloro-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 1040461-87-7 2-(N'-(4-nitro-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 1040461-76-4 2-(N'-benzylidene-hydrazino)-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 304446-59-1 2-(N'-(4-methoxy-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 1040461-92-4 2-(N'-(2-methyl-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 1040461-84-4 2-(N'-(2-nitro-benzylidene-hydrazino))-3-(2-methylphenyl)-3H-quinazolin-4-one 
• 67811-47-6 4-(o-tolyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 97978-79-5 1-methyl-4-o-tolyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 
• 899144-65-1 C₁₈H₁₆N₄O 
• 138597-71-4 C₁₇H₁₃ClN₄O 
• 1093123-41-1 C₁₉H₁₈N₄O 
• 67443-04-3 1-[3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl]-4-[phenyl] thiosemicarbazide 

Relevant articles and documents

Antimicrobial activities of some synthesized 1-(3-(2-methylphenyl)-4-Oxo-3H-quinazolin-2-yl-4-(substituted)thiosemicarbazide derivatives

The substituted thiosemicarbazide moiety was placed at the C-2 position and 2-methylphenyl group at N-3 position of quinazoline ring and obtained compounds were tested for their antitubercular activities and antibacterial activities against selected gram-positive and gram-negative bacteria. The target compounds 1-(3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides were obtained by the reaction of 2-hydrazino-3-(2-methylphenyl) quinazolin-4(3H)-one with different dithiocarbamic acid methyl ester derivatives. All synthesized compounds were also screened for their antimicrobial activity against selective gram-positive and gram-negative bacteria by agar dilution method. Among the series, 1-[3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl]-4-[4-chlorophenyl]-thiosemicarbazide exhibited the most potent activity against S. typhi, E. coli, and B. subtilis, while 1-[3-(2-methylphenyl)-4-oxo-3H-quinazolin-2-yl]-4-[4-nitrophenyl]-thiosemicarbazide was the most potent against E. coli, B. subtilis, P. aeruginosa, S. typhi, and S. flexneri. These two compounds exhibited the antitubercular activity at the minimum concentration (3 μg/mL) that offered potential for further optimization and development of new antitubercular agents. The obtained results demonstrated promising antimicrobial and antitubercular activities of the synthesized quinazoline compounds which could be used as new scaffolds for improving their antimicrobial activity.

Cynogen bromide and ethylacetoacetate in heterocyclization: Novel synthesis of tetracyclic derivative of 3-aryl quinazolinones

(Chemical Equation Presented) In this work, tricyclic 1-amino-4- (substituted phenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 3 was synthesized by treatment of 2-hydrazinyl-3-(substituted phenyl)quinazolin-4(3H)-one 2 with cyanogen bromide, which on cyc

Synthesis and pharmacological evaluation of some 3-(2-methylphenyl)-2- substituted amino-quinazolin-4(3H)-ones as analgesic and anti-inflammatory agents

A variety of novel 3-(2-methylphenyl)-2-substituted amino-quinazolin-4(3H)- ones were synthesized by reacting the amino group of 2-hydrazino-3-(2- methylphenyl)-quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(2-methylphenyl)-quinazolin-4(3H)-one was synthesized from 2-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. Among these, the compound 2-(1-ethylpropylidene)-hydrazino-3-(2-methylphenyl)-quinazolin-4(3H)- one emerged as the most active compound for analgesic activity, while the compound 2-(1-methylbutylidene)-hydrazino-3-(2-methylphenyl)-quinazolin-4(3H)- one showed most potent anti-inflammatory activity of the series and was moderately more potent in its anti-inflammatory activity when compared to the reference standard diclofenac sodium (CAS 15307-86-5). Interestingly, the test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid (CAS No: 50-78-2). ECV - Editio Cantor Verlag.