1040485-06-0Relevant academic research and scientific papers
Highly diastereo- and enantioselective direct Barbas-List aldol reactions promoted by novel benzamidoethyl and benzamidopropyl prolinamides in water
Pedrosa, Rafael,Andres, Jose M.,Manzano, Ruben,Roman, David,Tellez, Silvia
, p. 935 - 940 (2011/03/22)
Four novel benzamido-functionalized prolinamides have been prepared and tested as organocatalysts for enantioselective aldol reaction of aldehydes and cyclic ketones in water. In particular, prolinamide derived from achiral ethylene diamine was the best c
Highly enantio- and diastereoselective synthesis of α- trifluoromethyldihydropyrans using a novel bifunctional piperazine-thiourea catalyst
Li, Peng,Chai, Zhuo,Zhao, Sheng-Li,Yang, Ying-Quan,Wang, Hai-Feng,Zheng, Chang-Wu,Cai, Yue-Peng,Zhao, Gang,Zhu, Shi-Zheng
supporting information; experimental part, p. 7369 - 7371 (2010/06/14)
The first enantioselective Michael addition of α-cyanoketones to α,β-unsaturated trifluoromethyl ketones using a novel piperazine-thiourea catalyst was described. The resulting α- trifluoromethyldihydropyrans were obtained in high yields and with up to 95
Stereoselective synthesis of a novel chiral piperazine
Kojima, Satoshi,Chabayashi, Takashi,Umeda, Yasuhiro,Iwamoto, Akihisa,Tanabe, Kazuhisa,Ohkata, Katsuo
experimental part, p. 1493 - 1501 (2009/04/10)
(2S,6S)-2,4,6-Tris(phenylmethyl)piperazine was prepared in 11 steps and 53% overall yield from S-phenylalanine. Key steps in the synthesis involved reductive amination to introduce an ethoxycarbonylmethyl group on to the secondary nitrogen of the product
