104061-06-5Relevant academic research and scientific papers
1-[2-(2,4-dichlorophenyl)-2-(4-substituted piperazine)ethyl]-1H-imidazoles having antimycotic and antibacterial activities, pharmaceutical compositions containing them
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, (2008/06/13)
Compounds of formula I STR1 wherein R is a phenyl group; a phenyl group mono- or di-substituted by halogen atoms, methyl, methoxy, nitro, or trifluoromethyl group; or a 2-, 3- or 4-pyridyl group; and pharmaceutically acceptable acid addition salts thereof. Compounds I are prepared by reacting N-substituted piperazines with 1-(2',4'-dichloro-benzoylmetyl)-imidazole, optionally reducing thereafter the resulting enamines. Compounds I have antimycotic and antibacterial activities, higher than those of known comparison drugs.
Synthesis and microbiologic activity of a new class of imidazole derivatives
Stradi,Rossi,Dubini,Balsari,Desideri,Milanese
, p. 558 - 565 (2007/10/02)
The synthesis of a new class of imidazole derivatives with the structure of 1-[2-(2,4-dichlorophenyl)-2-tert.amino]ethylimidazoles is described. Preliminary data on their antimicrobial activity are reported.
